α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors Participate in the Analgesic but Not Hypnotic Effects of Emulsified Halogenated Anaesthetics
Lihua Hang
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorDonghua Shao
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorYinghong Yang
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorWenjin Sun
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorTijun Dai
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorYinming Zeng
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorLihua Hang
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorDonghua Shao
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorYinghong Yang
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorWenjin Sun
Department of Anesthesiology, the Affiliated People's Hospital of Jiangsu University and the First People's Hospital of Zhenjiang, Zhenjiang, China, and
Search for more papers by this authorTijun Dai
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorYinming Zeng
Jiangsu Province Key Laboratory of Anesthesiology and Jiangsu Province Institute of Anesthesiology, Xuzhou Medical College, Xuzhou, China
Search for more papers by this authorAbstract
Abstract: The present study was designed to investigate the role of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in hypnosis and analgesia induced by emulsified inhalation anaesthetics. After having established the mice model of hypnosis and analgesia by intraperitoneally injecting appropriate doses of emulsified enflurane, isoflurane or sevoflurane, we intracerebroventricularly or intrathecally injected different doses of AMPA and then observed the effects on the sleep time using hypnosis test and the tail-withdrawal latency using the tail-withdrawal test. In hypnosis test, AMPA (50, 75 and 100 ng, intracerebroventricularly) had no distinctive effects on the sleep time of the mice treated with emulsified inhalation anaesthetics (P > 0.05). In tail-withdrawal test, AMPA (0.25, 0.5 and 1.0 ng, intrathecally) significantly and dose-dependently decreased the tail-withdrawal latency (P < 0.05 or P < 0.01) in the mice treated with emulsified anaesthetics. These results suggest that AMPA receptors may participate in the analgesic but not in the hypnotic effects induced by emulsified enflurane, isoflurane or sevoflurane.
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