Licochalcone A Inhibits the Growth of Colon Carcinoma and Attenuates Cisplatin-Induced Toxicity without a Loss of Chemotherapeutic Efficacy in Mice
Chang Ki Lee
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorSeung Hwa Son
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Search for more papers by this authorKwang Kyun Park
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorJung Han Yoon Park
Department of Food Science and Nutrition, Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea, and
Search for more papers by this authorSoon Sung Lim
Department of Food Science and Nutrition, Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea, and
Search for more papers by this authorSook-Hyang Kim
Department of Dental Hygiene, Hanseo University, Chungcheongnam-do, South Korea
Search for more papers by this authorWon Yoon Chung
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorChang Ki Lee
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorSeung Hwa Son
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Search for more papers by this authorKwang Kyun Park
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorJung Han Yoon Park
Department of Food Science and Nutrition, Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea, and
Search for more papers by this authorSoon Sung Lim
Department of Food Science and Nutrition, Silver Biotechnology Research Center, Hallym University, Chunchon, South Korea, and
Search for more papers by this authorSook-Hyang Kim
Department of Dental Hygiene, Hanseo University, Chungcheongnam-do, South Korea
Search for more papers by this authorWon Yoon Chung
Department of Oral Biology, Oral Cancer Research Institute, Oral Science Research Institute, Brain Korea 21 Project, Yonsei University College of Dentistry, Seoul, South Korea,
Department of Applied Life Science, Graduate School, Yonsei University, Seoul, South Korea,
Search for more papers by this authorAbstract
Abstract: Although chemotherapy has an important function in the treatment of most solid tumours, its clinical applications are limited by severe side effects such as nephrotoxicity, hepatotoxicity, ototoxicity and neurotoxicity. Recently, a growing amount of attention has been focused on the investigation of the effects of chemopreventive agents on the inhibition of cancer cell growth and toxicity in combination with chemotherapeutics. The aim of this study was to determine whether licochalcone A (LCA) has the potential to serve as a beneficial supplement during cisplatin chemotherapy. We found that the administration of LCA alone significantly inhibited the size of the solid tumours in CT-26 cell-inoculated Balb/c mice, without any detectable induction of nephrotoxicity, hepatotoxicity and oxidative stress. LCA also suppressed cell proliferation by reducing DNA synthesis of CT-26 murine colon cancer cells in a dose-dependent manner. LCA did not affect the therapeutic efficacy of cisplatin. Furthermore, LCA inhibited the cisplatin-induced kidney damage characterized by increases in the serum creatinine and blood urea nitrogen, as well as the cisplatin-induced liver damage characterized by increases in the serum alanine aminotransferase and aspartate aminotransferase. The repeated oral administration of LCA prior to cisplatin treatment exerted a preventive effect on the cisplatin-mediated increases in the serum nitric oxide and the tissue lipid peroxidation levels, and recovered the depleted reduced glutathione levels in the tissues. These results suggest that supplementation with LCA may be beneficial in counteracting the side effects of cisplatin therapy in cancer patients.
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