Matrix-degrading proteases and angiogenesis during development and tumor formation
Corresponding Author
ZENA WERB
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Department of Anatomy, Box 0452, University of California, 3rd and Parnassus Avenues, San Francisco, CA 94143–0452, USA.Search for more papers by this authorTHIENNU H. VU
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Departments of Medicine, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorJULIE L. RINKENBERGER
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorLISA M. COUSSENS
Departments of Hormone Research Institute, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorCorresponding Author
ZENA WERB
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Department of Anatomy, Box 0452, University of California, 3rd and Parnassus Avenues, San Francisco, CA 94143–0452, USA.Search for more papers by this authorTHIENNU H. VU
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Departments of Medicine, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorJULIE L. RINKENBERGER
Departments of Anatomy, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorLISA M. COUSSENS
Departments of Hormone Research Institute, University of California, San Francisco, San Francisco, USA
Search for more papers by this authorAbstract
Embryonic development and tumor progression both require the exquisite coordination of programs for extracellular matrix (ECM) formation and remodeling, and those for angiogenesis and vascular development. Without a vascular supply the normal tissue or tumor is limited in size and organization. Without ECM remodeling the alteration of tissue and tumor boundaries and cellular migrations are limited. Recent insights into the molecular mechanisms regulating the extracellular environment of the growing embryonic tissue or tumors have implicated proteases, the matrix metalloproteinases (MMPs) in particular, in both the process of ECM remodeling and angiogenesis, and in a potential causal relationship between these processes. This review focuses on the roles that MMPs play in regulating three processes in which both proteolysis and vascular development are tightly coordinated: embryo implantation, bone development and tumor progression.
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