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Spontaneous squamous cell carcinomas of the oral region in domestic animals: a review and consideration of their relevance to human research
DG Gardner,
Corresponding Author
DG Gardner
Division of Oral Pathology and Oncology, University of Colorado School of Dentistry. Denver, CO, USA
*University of Colorado School of Dentistry, 4200 East Ninth Avenue, Campus Box C284, Denver, CO 80262, USASearch for more papers by this authorDG Gardner,
Corresponding Author
DG Gardner
Division of Oral Pathology and Oncology, University of Colorado School of Dentistry. Denver, CO, USA
*University of Colorado School of Dentistry, 4200 East Ninth Avenue, Campus Box C284, Denver, CO 80262, USASearch for more papers by this authorAbstract
Spontaneous squamous cell carcinomas of the oral region in domestic animals have the potential of providing additional information about the pathology of oral cancer and may be useful in therapeutic research. Moreover, they exhibit definite advantages over chemically induced tumors in rodents. This article provides background information on spontaneous oral squamous cell carcinomas in dogs, cats, cattle, horses and sheep and then discusses the use in research of such tumors in dogs and cats. These two species are potentially the most useful because they are numerous, suffer quite commonly from squamous cell carcinoma of the oral cavity and oro-pharynx, and are usually allowed to live approximately normal life spans. Moreover, they are being treated routinely in veterinary hospitals.
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