Comparative in vivo Lead Mobilization of meso- and rac-2,3-Dimercaptosuccinic Acids in Albino Wistar Rats
Corresponding Author
Mark M. Jones
1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U. S. A.
Author for correspondence: Mark M. Jones, Box 1583, Station B, Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U.S.A. (fax +1 (615) 322–4936).Search for more papers by this authorPramod K. Singh
1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U. S. A.
Search for more papers by this authorKrista Kostial
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorMaja Blanuša
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorMartina Piasek
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorNada Restek-Samarožija
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorCorresponding Author
Mark M. Jones
1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U. S. A.
Author for correspondence: Mark M. Jones, Box 1583, Station B, Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U.S.A. (fax +1 (615) 322–4936).Search for more papers by this authorPramod K. Singh
1 Department of Chemistry, Vanderbilt University, Nashville, TN 37235, U. S. A.
Search for more papers by this authorKrista Kostial
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorMaja Blanuša
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorMartina Piasek
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorNada Restek-Samarožija
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Republic of Croatia
Search for more papers by this authorAbstract
Abstract: Comparison of the racemic and meso forms of 2,3-dimercaptosuccinic acid (DMSA) in lead mobilization from lead-loaded albino Wistar rats demonstrates that the racemic form is significantly more effective in reducing femur lead levels. After four oral doses at 0.5 mmol/kg, femur lead levels were reduced to 87% of control values by meso-DMSA and to 50% of control levels by rac-DMSA. Similarly, when the dose was increased to 1.0 mmol/kg, femur lead levels were reduced to 69% of control levels by meso-DMSA and to 45% of control levels by rac-DMSA. A similar pattern was found for renal lead levels. Brain lead concentrations were significantly lower in treated groups than in control groups, but no differences were found between rac- and meso-DMSA. Rac-DMSA is more soluble than meso-DMSA in acetonitrile, ethyl acetate, and ethyl ether. The partition coefficient of rac-DMSA in the n-octanol/water system was found to be about 2.8. These results indicate that rac-DMSA deserves further attention as a possible substitute for meso-DMSA.
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