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Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

J. R. Østergaard

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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K. Østergaard,

K. Østergaard

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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K.-E. Andersson,

K.-E. Andersson

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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L. Sommer,

L. Sommer

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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J. R. Østergaard,

J. R. Østergaard

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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K. Østergaard,

K. Østergaard

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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K.-E. Andersson,

K.-E. Andersson

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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L. Sommer,

L. Sommer

From the Department of Clinical Pharmacology, Institute of Pharmacology, University of Aarhus, Aarhus, Denmark, and the Department of Clinical Pharmacology, University Hospital, Lund, Sweden

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First published: April 1980

https://doi.org/10.1111/j.1600-0773.1980.tb03243.x

Citations: 21

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Abstract

Abstract The possible calcium antagonistic action of the anti-anginal drug terodiline was investigated by two experimental techniques. In isolated preparations of rabbit aorta and pregnant human uterus exposed to a calcium-free medium and then depolarized by potassium, terodiline in concentrations of 4.5–36 μM inhibited contractions produced by cumulative addition of calcium to the extracellular medium. This effect of terodiline could be reversed by high concentrations of calcium. Within the same concentration range, terodiline also reduced potassium-induced ⁴⁵Ca influx in isolated aorta without affecting calcium efflux. It is suggested that terodiline, which structurally has similarities to prenylamine and fendiline, like these drugs can be classified as a calcium antagonist.

References

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Volume46, Issues1

April 1980

Pages 12-19

Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

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Calcium antagonistic effects of terodiline in rabbit aorta and human uterus

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