Prenatal stress programs lipid metabolism enhancing cardiovascular risk in the female F1, F2, and F3 generation in the primate model common marmoset (Callithrix jacchus)
Ulrike Buchwald
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorDaniel Teupser
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
Search for more papers by this authorFriederike Kuehnel
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorJana Grohmann
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorNancy Schmieder
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorNicola Beindorff
Department of Reproductive Biology, German Primate Center, Göttingen, Germany
Search for more papers by this authorChristina Schlumbohm
Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany
Search for more papers by this authorHerbert Fuhrmann
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorAlmuth Einspanier
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorUlrike Buchwald
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorDaniel Teupser
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital Leipzig, Leipzig, Germany
Search for more papers by this authorFriederike Kuehnel
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorJana Grohmann
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorNancy Schmieder
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorNicola Beindorff
Department of Reproductive Biology, German Primate Center, Göttingen, Germany
Search for more papers by this authorChristina Schlumbohm
Clinical Neurobiology Laboratory, German Primate Center, Göttingen, Germany
Search for more papers by this authorHerbert Fuhrmann
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
Search for more papers by this authorAlmuth Einspanier
Institute of Physiological Chemistry, Veterinary Faculty, University of Leipzig, Leipzig, Germany
LIFE – Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany
Search for more papers by this authorAbstract
Background Many human diseases are modulated by intrauterine environment, which is called prenatal programming. This study investigated effects of prenatal glucocorticoids on the lipid metabolism of three filial generations of common marmosets.
Methods Pregnant primates were treated with dexamethasone during pregnancy. Body weight and blood lipid parameters of adult female offspring (F1: n = 5, F2: n = 6, F3: n = 3) were compared with age-related female controls (n = 12).
Results F1, F2, and F3 offspring showed significantly lower percentage of plasma n3 fatty acids than controls. F2 and F3 presented higher cholesterol levels, with significantly more LDL cholesterol, significantly less HDL triglycerides and an enhanced cholesterol/HDL cholesterol ratio. Body weight was not significantly affected.
Conclusions Prenatal dexamethasone led to higher amounts of cardiovascular risk factors and less protective parameters in female F1–F3 offspring. The intergenerational consequences suggest prenatal programming through epigenetic effects.
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