Volume 37, Issue 4 pp. 491-496

CD4/CD8 double negative pagetoid reticulosis: a case report and literature review

Nikki Mourtzinos,

Nikki Mourtzinos

Department of Pathology, George Washington University Hospital, Washington, DC, USA

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Puja K. Puri,

Puja K. Puri

Department of Pathology, Duke University Medical Center, Durham, NC, USA

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Guanghua Wang,

Guanghua Wang

Department of Molecular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA

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Min-Ling Liu,

Corresponding Author

Min-Ling Liu

Department of Pathology, George Washington University Hospital, Washington, DC, USA

Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, USA

Min-Ling Liu, Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, 50 Irving Street, N.W., Washington, DC 20422, USA
Tel: +1 202 745 8249
Fax: +1 202 745 8284
e-mail: [email protected]Search for more papers by this author

Nikki Mourtzinos,

Nikki Mourtzinos

Department of Pathology, George Washington University Hospital, Washington, DC, USA

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Puja K. Puri,

Puja K. Puri

Department of Pathology, Duke University Medical Center, Durham, NC, USA

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Guanghua Wang,

Guanghua Wang

Department of Molecular Pathology, Armed Forces Institute of Pathology, Washington, DC, USA

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Min-Ling Liu,

Corresponding Author

Min-Ling Liu

Department of Pathology, George Washington University Hospital, Washington, DC, USA

Pathology and Laboratory Medicine Service, Veterans Affairs Medical Center, Washington, DC, USA

First published: 11 February 2010

https://doi.org/10.1111/j.1600-0560.2009.01323.x

Citations: 23

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Abstract

Pagetoid reticulosis is an indolent primary cutaneous T-cell lymphoma. It typically presents as a solitary and slowly growing patch or plaque on the extremity, histologically characterized by an acanthotic epidermis infiltrated with atypical lymphocytes. Here, we present histological, immunophenotypical and molecular findings of a 29-year-old Jamaican man with bilateral wrist plaques. Histology showed marked acanthosis, hyperkeratosis and an intraepidermal infiltration consisting of large atypical lymphocytes. Immunohistochemical stains showed CD3 and CD5 positive T cells with significant loss of CD7, double negative CD4 and CD8 and strong positive CD30. Molecular analysis showed a monoclonal T-cell receptor (TCR) gamma gene rearrangement. Review of the literature confirms that the immunophenotype of pagetoid reticulosis is variable with decreasing frequency of CD8+ cytotoxic/suppressor T cell, CD4+ helper T cell and least commonly CD4/CD8 double negative phenotypes. Although CD4/CD8 double negative phenotype appears to be associated with higher proliferation index, it does not appear to confer prognostic significance.

Mourtzinos N, Puri PK, Guanghua W, Liu M-L. CD4/CD8 double negative pagetoid reticulosis: a case report and literature review.

References

1 Willemze R, Jaffe ES, Burg G, et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005; 105: 3768.
10.1182/blood-2004-09-3502
CAS PubMed Web of Science® Google Scholar
2 Steffen C. Ketron-Goodman disease, Woringer-Kolopp disease, and pagetoid reticulosis. Am J Dermatopathol 2005; 27: 68.
10.1097/01.dad.0000144160.26647.ab
PubMed Web of Science® Google Scholar
3 Braun-Falco O, Marghescu S, Wolff HH. Pagetoid reticulosis. Morbus Woringer-Kolopp. Hautarzt 1973; 24: 11.
CAS PubMed Web of Science® Google Scholar
4 Mielke V, Wolff HH, Winzer M, Sterry W. Localized and disseminated pagetoid reticulosis. Diagnostic immunophenotypical findings. Arch Dermatol 1989; 125: 402.
PubMed Web of Science® Google Scholar
5 Haghighi B, Smoller BR, LeBoit PE, Warnke RA, Sander CA, Kohler S. Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopathologic study. Mod Pathol 2000; 13: 502.
10.1038/modpathol.3880088
CAS PubMed Web of Science® Google Scholar
6 Krafft AE, Taubenberger JK, Sheng ZM, et al. Enhanced sensitivity with a novel TCR gamma PCR assay for clonality studies in 569 formalin-fixed, paraffin-embedded (FFPE) cases. Mol Diagn 1999; 4: 119.
10.1016/S1084-8592(99)80036-8
CAS PubMed Web of Science® Google Scholar
7 Jacyk WK, Grayson W, Dinkel JE, Requena L. Pagetoid reticulosis with CD30 positivity and cytotoxic/suppressor cells. J Cutan Pathol 2007; 34: 644.
10.1111/j.1600-0560.2006.00698.x
PubMed Web of Science® Google Scholar
8 Wu H, Telang GH, Lessin SR, Vonderheid EC. Mycosis fungoides with CD30-positive cells in the epidermis. Am J Dermatopathol 2000; 22: 212.
10.1097/00000372-200006000-00002
CAS PubMed Web of Science® Google Scholar
9 Vergier B, De Muret A, Beylot-Barry M, et al. Transformation of mycosis fungoides: clinicopathological and prognostic features of 45 cases. French Study Group of Cutaneious Lymphomas. Blood 2000; 95: 2212.
CAS PubMed Web of Science® Google Scholar
10 Mackie RM, Turbitt ML. A case of pagetoid reticulosis bearing the T cytotoxic suppressor surface marker on the lymphoid infiltrate: further evidence that pagetoid reticulosis is not a variant of mycosis fungoides. Br J Dermatol 1984; 110: 89.
10.1111/j.1365-2133.1984.tb07317.x
PubMed Web of Science® Google Scholar
11 Wood GS, Weiss LM, Hu CH, et al. T-cell antigen deficiencies and clonal rearrangements of T-cell receptor genes in pagetoid reticulosis (Woringer-Kolopp disease). N Engl J Med 1988; 318: 164.
10.1056/NEJM198801213180307
CAS PubMed Web of Science® Google Scholar
12 Burns MK, Chan LS, Cooper KD. Woringer-Kolopp disease (localized pagetoid reticulosis) or unilesional mycosis fungoides? An analysis of eight cases with benign disease. Arch Dermatol 1995; 131: 325.
10.1001/archderm.1995.01690150089018
CAS PubMed Web of Science® Google Scholar
13 Drillenburg P, Bronkhorst CM, Van Der Wal AC, Noorduyn LA, Hoekzema R, Pals ST. Expression of adhesion molecules in pagetoid reticulosis (Woringer-Kolopp disease). Br J Dermatol 1997; 136: 613.
10.1046/j.1365-2133.1997.d01-1247.x
CAS PubMed Web of Science® Google Scholar
14 McNiff JM, Schechner JS, Crotty PL, Glusac EJ. Mycosis fungoides palmaris et plantaris or acral pagetoid reticulosis? Am J Dermatopathol 1998; 20: 271.
10.1097/00000372-199806000-00009
CAS PubMed Web of Science® Google Scholar
15 Palmer RA, Keefe M, Slater D, Whittaker SJ. Case 4: pagetoid reticulosis (Woringer-Kolopp type) or unilesional mycosis fungoides (MF). Clin Exp Dermatol 2002; 27: 345.
10.1046/j.1365-2230.2002.01044.x
PubMed Web of Science® Google Scholar
16 Scarabello A, Fantini F, Giannetti A, Cerroni L. Localized pagetoid reticulosis (Woringer-Kolopp disease). Br J Dermatol 2002; 147: 806.
10.1046/j.1365-2133.2002.04788.x
CAS PubMed Web of Science® Google Scholar
17 Sedghizadeh PP, Allen CM, Kalmer JR, Magro CM. Pagetoid reticulosis: a case report and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2003; 95: 318.
10.1067/moe.2003.3
PubMed Web of Science® Google Scholar
18 Hodak E, David M, Maron L, Aviram A, Kaganovsky E, Feinmesser M. CD4/CD8 double-negative epidermotropic cutaneous T-cell lymphoma: an immunohistochemical variant of mycosis fungoides. J Am Acad Dermatol 2006; 55: 276.
10.1016/j.jaad.2006.01.020
PubMed Web of Science® Google Scholar
19 Lee J, Viakhireva N, Cesca C, et al. Clinicopathologic features and treatment outcomes in Woringer-Kolopp disease. J Am Acad Dermatol 2008; 59: 706.
10.1016/j.jaad.2008.04.018
PubMed Web of Science® Google Scholar
20 Miedler JD, Kristjansson AK, Gould J, Tamburro J, Gilliam AC. Pagetoid reticulosis in a 5-year-old boy. J Am Acad Dermatol 2008; 58: 679.
10.1016/j.jaad.2007.07.030
PubMed Web of Science® Google Scholar
21 Skiljevic D, Bogdanovic Z, Vesic S, Vukicevic-Sretenovic J, Gajic-Veljic M, Medenica L. Pagetoid reticulosis of Woringer-Kolopp. Dermatol Online J 2008; 14: 18.
PubMed Google Scholar
22 Deneau DG, Wood GS, Beckstead J, Hoppe RT, Price N. Woringer-Kolopp disease (pagetoid reticulosis). Four cases with histopathologic, ultrastructural and immunohistologic observations. Arch Dermatol 1984; 120: 1045.
CAS PubMed Web of Science® Google Scholar
23 Jones D, Vega F, Sarris AH, Medeiros LJ. CD4–CD8–“Double-negative” cutaneous T-cell lymphomas share common histologic features and an aggressive clinical course. Am J Surg Pathol 2002; 26: 225.
10.1097/00000478-200202000-00009
PubMed Web of Science® Google Scholar
24 Pagnanelli G., Bianchi L, Cantonetti M, et al. Disseminated pagetoid reticulosis presenting as cytotoxic CD4/CD8 double negative cutaneous T-cell lymphoma. Acta Derm Venereol 2002; 82: 314.
10.1080/000155502320323388
CAS PubMed Web of Science® Google Scholar
25 Berti E, Cerri A, Cavicchini S, et al. Primary cutaneous gamma/delta T-cell lymphoma presenting as disseminated pagetoid reticulosis. J Invest Dermatol 1991; 96: 718.
10.1111/1523-1747.ep12470953
CAS PubMed Web of Science® Google Scholar
26 Shiozawa E, Shiokawa A, Shibata M, et al. Autopsy case of CD4/CD8 cutaneous T-cell lymphoma presenting disseminated pagetoid reticulosis with aggressive granulomatous invasion to the lungs and pancreas. Pathol Int 2005; 55: 32.
10.1111/j.1440-1827.2005.01785.x
CAS PubMed Web of Science® Google Scholar

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Volume37, Issue4

April 2010

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CD4/CD8 double negative pagetoid reticulosis: a case report and literature review

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CD4/CD8 double negative pagetoid reticulosis: a case report and literature review

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