Allergic contact dermatitis from chloromethyl heterocyclic intermediate the synthesis of a histamine antagonist

Case reports of 3 chemists who worked in a laboratory where heterocyclic chloromethyl compounds, used as intermediates in the synthesis of a histamine antagonist, were being prepared, are here presented. The results of suitable patch tests which were applied arc reported and it is concluded from the results that 3 chemical intermediates were responsible for the allergic contact dermatitis in the 3 cases.