Open flap debridement and guided tissue regeneration after 10 years in infrabony defects
Katrin Nickles
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorPetra Ratka-Krüger
Section of Periodontology, Department of Operative Dentistry and Periodontology, University Medical Center Freiburg, Dental School and Hospital, Freiburg, Germany
Search for more papers by this authorPeter Raetzke
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorPeter Eickholz
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorKatrin Nickles
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorPetra Ratka-Krüger
Section of Periodontology, Department of Operative Dentistry and Periodontology, University Medical Center Freiburg, Dental School and Hospital, Freiburg, Germany
Search for more papers by this authorPeter Raetzke
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorPeter Eickholz
Department of Periodontology, Center for Dental, Oral and Maxillofacial Medicine (Carolinum), Johann Wolfgang Goethe-University Frankfurt am Main, Frankfurt am Main, Germany
Search for more papers by this authorConflict of Interest and Source of Funding The authors declare that they have no conflict of interests.This study was in part self-funded by the authors and their institutions and in part funded by the German Society of Dental, Oral, and Maxillofacial Medicine (Deutsche Gesellschaft für Zahn-, Mund- und Kieferheilkunde: DGZMK).
Abstract
Objective: Evaluation of the 10-year results after open flap debridement (OFD) and guided tissue regeneration (GTR) therapy of infrabony defects in a randomized controlled clinical trial.
Materials and Methods: In 16 periodontitis patients OFD or polylactide acetyltributyl citrate barriers (GTR; n=23) were assigned randomly to 44 infrabony defects. In a subgroup of 10 patients exhibiting 2 contra-lateral defects each OFD and GTR was assigned to either side (split-mouth). At baseline, 12, and 120 ± 12 months after surgery clinical parameters were obtained.
Results: Fifteen patients (41 defects) were available at 120 months. Twelve and 120 ± 12 months after therapy both groups showed statistically significant (p<0.01) attachment gain (split-mouth: OFD: 12 months: 3.60 ± 2.67 mm; 120 months: 3.65 ± 3.36 mm; GTR: 12 months: 3.50 ± 1.90 mm; 120 months: 2.85 ± 2.24 mm; parallel: OFD: 12 months: 3.47 ± 2.80 mm; 120 months: 3.41 ± 2.75 mm; GTR: 12 months: 3.67 ± 2.11 mm; 120 months: 2.89 ± 2.12 mm). From 12 to 120 months both groups experienced insignificant attachment changes, however, six teeth (two OFD, four GTR) were lost (all for prosthodontic reasons). The study failed to show statistically significant attachment gain differences between both groups after 120 months.
Conclusions: Ten years after OFD and GTR in infrabony defects 35 of 41 teeth were still in place.
Supporting Information
Table S1. Checklist of items to include when reporting a randomized trial (56–58).
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