Gastric carcinosarcoma with neuroendocrine differentiation as the carcinoma component and leiomyosarcomatous and myofibroblastic differentiation as the sarcomatous component^†

Case report

Corresponding Author

N. KURODA

Departments of Pathology and Laboratory Medicine,

Naoto Kuroda, Department of Pathology and Laboratory Medicine, Kochi Red Cross Hospital, Shin-honmachi 2-chome 13–51, Kochi City, Kochi 780-8562, Japan. e-mail: [email protected]Search for more papers by this author

K. OONISHI,

K. OONISHI

Surgery and

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S. IWAMURA,

S. IWAMURA

Internal Medicine, Kochi Red Cross Hospital, Kochi, and

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M. OHARA,

M. OHARA

Departments of Pathology and Laboratory Medicine,

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T. HIROUCHI,

T. HIROUCHI

Departments of Pathology and Laboratory Medicine,

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K. MIZUMO,

K. MIZUMO

Departments of Pathology and Laboratory Medicine,

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E. MIYAZAKI,

E. MIYAZAKI

Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

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H. ENZAN,

H. ENZAN

Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

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N. KURODA,

Corresponding Author

N. KURODA

Departments of Pathology and Laboratory Medicine,

K. OONISHI,

K. OONISHI

Surgery and

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S. IWAMURA,

S. IWAMURA

Internal Medicine, Kochi Red Cross Hospital, Kochi, and

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M. OHARA,

M. OHARA

Departments of Pathology and Laboratory Medicine,

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T. HIROUCHI,

T. HIROUCHI

Departments of Pathology and Laboratory Medicine,

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K. MIZUMO,

K. MIZUMO

Departments of Pathology and Laboratory Medicine,

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E. MIYAZAKI,

E. MIYAZAKI

Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

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H. ENZAN,

H. ENZAN

Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan

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First published: 24 April 2006

https://doi.org/10.1111/j.1600-0463.2006.apm_328.x

Citations: 21

^†

Received 30 August 2005.

Accepted 7 November 2005.

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Abstract

Gastric carcinosarcoma with neuroendocrine differentiation is a very rare neoplasm. In this article we present such a case. The gastroendoscopic examination of a 59-year-old Japanese man disclosed gastric cancer during follow-up after operation for rectal cancer. Subsequently, total gastrectomy was carried out because of gastric cancer. A large tumor measuring 9.2×8.4 cm was observed in the posterior wall of the upper portion of the stomach. The tumor was composed of carcinoma and sarcomatous cells, and the histological transition of both components was observed. Immunohistochemically, carcinoma and sarcomatous cells were positive for cytokeratin CAM5.2. The carcinoma contained adenocarcinoma and malignant cells with neuroendocrine differentiation. The sarcomatous component showed leiomyosarcomatous and myofibroblastic differentiation. The present tumor is the fifth case of gastric carcinosarcoma with neuroendocrine differentiation and the first case of gastric carcinosarcoma with myofibroblastic differentiation. Pathologists should bear in mind that gastric carcinosarcoma may show various types of differentiation.

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Volume114, Issue3

March 2006

Pages 234-238

Gastric carcinosarcoma with neuroendocrine differentiation as the carcinoma component and leiomyosarcomatous and myofibroblastic differentiation as the sarcomatous component^†

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Gastric carcinosarcoma with neuroendocrine differentiation as the carcinoma component and leiomyosarcomatous and myofibroblastic differentiation as the sarcomatous component†

Case report

Abstract

REFERENCES

Citing Literature

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Gastric carcinosarcoma with neuroendocrine differentiation as the carcinoma component and leiomyosarcomatous and myofibroblastic differentiation as the sarcomatous component^†