Tenascin-C expression in Merkel cell carcinoma lymph node metastasis^†

Corresponding Author

VIRVE KOLJONEN

Department of Plastic Surgery, Helsinki University Hospital,

Virve Koljonen, Department of Plastic Surgery, Töölö Hospital, P.O. Box 266, FIN 0029 HUS, Finland. e-mail: [email protected]Search for more papers by this author

TOM BÖHLING,

TOM BÖHLING

Department of Pathology, Helsinki University and HUSLAB, and

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ERKKI TUKIAINEN,

ERKKI TUKIAINEN

Department of Plastic Surgery, Helsinki University Hospital,

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CAJ HAGLUND,

CAJ HAGLUND

Department of Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland

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TIINA JAHKOLA,

TIINA JAHKOLA

Department of Plastic Surgery, Helsinki University Hospital,

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VIRVE KOLJONEN,

Corresponding Author

VIRVE KOLJONEN

Department of Plastic Surgery, Helsinki University Hospital,

Virve Koljonen, Department of Plastic Surgery, Töölö Hospital, P.O. Box 266, FIN 0029 HUS, Finland. e-mail: [email protected]Search for more papers by this author

TOM BÖHLING,

TOM BÖHLING

Department of Pathology, Helsinki University and HUSLAB, and

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ERKKI TUKIAINEN,

ERKKI TUKIAINEN

Department of Plastic Surgery, Helsinki University Hospital,

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CAJ HAGLUND,

CAJ HAGLUND

Department of Gastroenterological and General Surgery, Helsinki University Hospital, Helsinki, Finland

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TIINA JAHKOLA,

TIINA JAHKOLA

Department of Plastic Surgery, Helsinki University Hospital,

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First published: 23 February 2006

https://doi.org/10.1111/j.1600-0463.2006.apm_249.x

Citations: 8

^†

Received 10 April 2005.

Accepted 1 November 2005.

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Abstract

Expression of tenascin-C (Tn-C) has been shown to correlate with invasion and metastasis in Merkel cell carcinoma (MCC). Cytokeratin-20 (CK-20) is used in differential diagnostics of the primary tumour. The aim of this study was to demonstrate the expression of Tn-C in MCC lymph node metastases. Immunohistochemical staining was performed for five metastatic lymph nodes using a monoclonal antibody against Tn-C and CK-20. All five metastatic lymph nodes expressed Tn-C. The expression concentrated around the vascular structures, invasion borders and fibrotic septae. One of the metastatic lymph nodes was strongly positive for CK-20 while the others showed a focal or negative pattern. The normal lymphoid tissue was negative for Tn-C. Tn-C detected metastatic MCC tissue within the lymph nodes undisputedly. There was a clear distinction between the metastatic and normal lymphatic tissue. Furthermore, invasion to the surrounding tissue was easily demonstrated. Contrary to previous studies, CK-20 expression seemed to fluctuate.

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Volume114, Issue1

January 2006

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Tenascin-C expression in Merkel cell carcinoma lymph node metastasis^†

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Tenascin-C expression in Merkel cell carcinoma lymph node metastasis†

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Tenascin-C expression in Merkel cell carcinoma lymph node metastasis^†