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Interaction between sleep and growth hormone
Evaluated by manual polysomnography and automatic power spectrum analysis
C. Åström,
Corresponding Author
C. Åström
Department of Clinical Neurophysiology, The National Hospital, Rigshospitalet, Copenhagen, Denmark
Christina Åström, University Clinic of Neurology, Hvidovre Hospital, DK-2650 Copenhagen, DenmarkSearch for more papers by this authorC. Åström,
Corresponding Author
C. Åström
Department of Clinical Neurophysiology, The National Hospital, Rigshospitalet, Copenhagen, Denmark
Christina Åström, University Clinic of Neurology, Hvidovre Hospital, DK-2650 Copenhagen, DenmarkSearch for more papers by this authorList of terminology in sleep and important abbreviations. Terminology used to describe the sleep pattern followed the international criteria of Rechtschaffen and Kales: Stage 1 to 4 sleep: Stage 1 is the transition from wakefulness to sleep and stages 2–4 are increasing depths of sleep. Delta sleep: = stage 3 + 4, slow wave sleep, “deep sleep”. Stage REM-sleep: Rapid eye movement sleep, referring to the conjugated eye-movements associated with the elaboration of dreams. Sleep onset: The start of first epoch of stage 2 sleep. Sleep latency: The time from lights out, to the beginning of the first stage 2 epoch. REM sleep latency: The time from sleep onset to the beginning of the first REM sleep epoch. Recording time: Time from lights out to final awakening (lights on). WASO: wake time after sleep onset. Total sleep time: Recording time minus sleep latency minus wake time after sleep onset, (TST). Sleep efficiency: Ratio between total sleep time and total recording time. Sleep cycle: First sleep cycle: from first stage 2 to onset of first stage REM. The following sleep cycles: from onset of one REM period to the onset of the next REM period.
Abstract
The relation between nightly growth hormone (GH) secretion and sleep is poorly understood. To examine whether disturbances in GH secretion are reflected in abnormal sleep patterns 8 subjects with isolated GH deficiency and 9 subjects with excess of GH (acromegalics) underwent all night sleep studies, polysomnography. Moreover, the effect of correcting GH concentration on sleep patterns were examined in the same subjects. The results showed that all subjects with GH disturbances had abnormal REM and delta sleep and normalization of GH concentration was followed by correction of the sleep stages. By power spectrum analysis of the sleep EEG it was showed that during low GH concentration the sleep energy was low, and high GH concentration was associated with high sleep energy, and correction of abnormal plasma GH levels resulted in normalization of REM and delta sleep energy per time unit.
Abbreviations:
-
- BMI
-
- Body mass index (kg/m2)
-
- CT
-
- Computer tomography
-
- CDSA
-
- Color density spectral array
-
- EEG
-
- Electroencephalogram
-
- EMG
-
- Electrornyogram
-
- EOG
-
- Electrooculogram
-
- GH
-
- Growth hormone
-
- GHD
-
- Growth hormone deficiency
-
- GRF
-
- Growth hormone releasing factor
-
- GF-1
-
- Insulin-like growth factor 1, same as somatomedine C (SMC)
-
- IGHD
-
- Isolated growth hormone deficiency
-
- MR
-
- Magnetic resonance
-
- OSAS
-
- Obstructive sleep apnea syndrome
-
- TST
-
- Total sleep time (in minutes)
-
- μ2/Hz
-
- Powerdensity
-
- μV2
-
- Power
-
- μV2s
-
- Energy power integrated over time
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