White Matter Lesion Load Increases the Risk of Low CSF Aβ42 in Apolipoprotein E-ɛ4 Carriers Attending a Memory Clinic
Vidar Stenset MD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorDag Hofoss PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorLisbeth Johnsen MSc
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAudun Elnaes Berstad MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAnne Negaard MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAnders Skinningsrud MD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorLeif Gjerstad MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorTormod Fladby MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorVidar Stenset MD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorDag Hofoss PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorLisbeth Johnsen MSc
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAudun Elnaes Berstad MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAnne Negaard MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorAnders Skinningsrud MD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorLeif Gjerstad MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorTormod Fladby MD, PhD
From the Departments of Neurology (VS, LJ, TF), Radiology (AEB, AN), and Multidisciplinary Medical Laboratory (AS), Akershus University Hospital, Lørenskog, Norway; Faculty Division, Akershus University Hospital, University of Oslo, Oslo, Norway (VS, TF); Department of Neurosurgery, Oslo University Hospital Ullevål, Oslo, Norway (VS); Helse Øst Health Services Research Centre, Akershus University Hospital, University of Oslo, Oslo, Norway (DH), Department of Neurology, Oslo University Hospital Rikshospitalet (LG), Oslo, Norway; and Medical Faculty, University of Oslo, Oslo, Norway (LG).
Search for more papers by this authorJ Neuroimaging 2011;21:e78-e82.
Abstract
ABSTRACT
BACKGROUND
White matter lesions (WMLs) are age-related manifestations of ischemic cerebrovascular disease and increase the risk for Alzheimer's disease (AD). The apolipoprotein E (ApoE) ɛ4 allele is a risk factor for late onset AD and has been related to low cerebrospinal fluid (CSF) Aβ42 levels and to cerebrovascular disease. The present study analyzed the relationship between WMLs, ApoE-ɛ4 genotype, and low CSF Aβ42.
METHODS
A total of 235 memory clinic attenders were stratified in 3 groups according to WML load. WMLs were rated on axial T2 magnetic resonance imaging images. Group 1 had no or only small amounts of periventricular (PV) or subcortical (SC) WMLs, WML group 2 had high amounts of PV WMLs and low amounts of SC WMLs, and WML group 3 had high amounts of both PV and SC WMLs. In each WML group, ApoE-ɛ4 genotype was used in logistic regression as a predictor for low CSF Aβ42 (cutoff ≤450 ng/L). Results: The odds ratio (OR) of having low CSF Aβ42 was significantly increased in the presence of ApoE-ɛ4 only in WML group 3 (OR 3.69, P= .009).
CONCLUSION
A high WML load may interact with the ApoE-ɛ4 genotype and increase the risk for reduced CSF Aβ42 in patients attending a memory clinic.
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