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Strain-Dependent Thermosensitivity Influencing Intracellular Differentiation of Trypanosoma cruzi in Cell Culture*

Z. BRENER

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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R. GOLGHER,

R. GOLGHER

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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M. S. BERTELLI,

M. S. BERTELLI

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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J. A. TEIXEIRA,

J. A. TEIXEIRA

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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Z. BRENER,

Z. BRENER

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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R. GOLGHER,

R. GOLGHER

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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M. S. BERTELLI,

M. S. BERTELLI

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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J. A. TEIXEIRA,

J. A. TEIXEIRA

Department of Parasitology and Microbiology, I. C. B., University of Minas Gerais and Instituto Nacional de Endemias Rurais, C. Postal 1743, Belo Horizonte, M. G.

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First published: February 1976

https://doi.org/10.1111/j.1550-7408.1976.tb05258.x

Citations: 14

^†

This investigation was supported by the National Research Council, Brazil, and the Research Council of the University of Minas Gerais.

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Abstract

SYNOPSIS. Temperature strongly influenced morphogenesis of intracellular trypomastigotes in cell culture infected with 2 different strains of T. cruzi. With the Gilmar strain the amastigote-to-trypomastigote differentiation readily occurred at 33 and 37 C, whereas with the CL strain differentiation took place at 33 C but was inhibited at 37 C. The possibility of this selective thermosensitivity resulting from mutational adaptation of the parasite is discussed.

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Volume23, Issue1

February 1976

Pages 147-150

Strain-Dependent Thermosensitivity Influencing Intracellular Differentiation of Trypanosoma cruzi in Cell Culture*

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Strain-Dependent Thermosensitivity Influencing Intracellular Differentiation of Trypanosoma cruzi in Cell Culture*

Abstract

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