SYNOPSIS. A rapid quantitative method for measuring trypanostatic activity by means of the nonpathogenic flagellate Herpetomonas culicidarum is described. Of the known trypanocidal agents tested, pentamidine was the most active; stilbamidine and propamidine somewhat less active. H. culicidarum is more resistant to these agents than are some pathogenic hemoflagellates. Two new antifungal antibiotics, nystatin and heptamycin (a candicidin-like antibiotic), had powerful trypanostatic activity in vitro. The potential trypanostatic activity of antifungal agents is noted.

References

1 Adler, S. & Tchernomoretz, I. (1939). The action of 4,4prime; -diamidino stilbene on Leishmania donovani in the Syrian hamster Cricetus auratus. Ann. Trop. Med. Parasitol., 33, 313–322.
CAS Google Scholar
2 Adler, S., Tchernomoretz, I. & Ber, M. (1945). The action of some aromatic diamidines on cultures of Leishmania donovani. Ann. Trop. Med. Parasitol., 39, 14–18.
CAS Web of Science® Google Scholar
3 Campbell. C. C., Hodges, E. P. & Hill, G. B. (1954). Therapeutic effect of Nystatin (fungicidin) in mice experimentally infected with Histoplasma capsulatum. Antibiotics & Chemotherapy, 4, 406–410.
CAS Web of Science® Google Scholar
4 Campbell, C. C., O'Dell, E. T. & Hill, G. B. (19541955). Therapeutic activity of Nystatin in experimental systemic mycotic infections. Antibiotics Ann. , 858–862.
Google Scholar
5 Christison, I. B. & Conant, N. F. (1953). Antifungal activity of some aromatic diamidines. J. Lab. Clin. Med., 42, 638–640.
CAS PubMed Web of Science® Google Scholar
6 Citri, N. & Grossowicz, N. (1955). A partially defined medium for Trypanosoma cruzi and some other haemoflagellates. J. Gen. Microbiol., 13, 273–278.
10.1099/00221287-13-2-273
CAS PubMed Web of Science® Google Scholar
7 Grossowicz, N. & Citri, N. (1955). Cultivation of Leishmania tropica under defined conditions. Harefuah, 49, 119–122.
CAS PubMed Google Scholar
8 Magara, M., Yokouti, E., Senda, T. & Amino, E. (1954). Action of a new antibiotic, trichomycin, on Trichomonas vaginalis, Candida albicans and anaerobic bacteria. Antibiotics & Chemotherapy. 4, 433–438.
CAS Web of Science® Google Scholar
9 Nathan, H. A. & Cowperthwaite, J. (1954). Use of the trypanosomid flagellate, Crithidia fasciculata, for evaluating antimalarials. Proc. Soc. Exptl. Biol. Med., 85, 117–119.
10.3181/00379727-85-20803
CAS PubMed Web of Science® Google Scholar
10 Tobie, E. J. The effect of Puromycin on six species of Trypanosoma in mice. Am. J. Trop. Med. Hyg., 3, 852–859.
Google Scholar
11 Trincão, C., Nugueira, A. & Franco, A. (1955). Puromycin studies in experimental Trypanosoma gambiense and Trypanosoma rhodesiense infections in mice. Antibiotics & Chemotherapy, 5, 505–507.
CAS Google Scholar
12 Waksman, S. A. & Lechevalier, H. A. (1953). Sensitivity of actinomycetales to isonicotinic acid hydrazide, compared to other synthetic and antibiotic antituberculous agents. Am. Rev. Tuberc., 67, 261–264.
CAS PubMed Web of Science® Google Scholar
13 Waksman, S. A. & Lechevalier, H. A. (1953). Actinomyces and Their Antibiotics. Williams & Wilkins, Baltimore , p. 198.
Google Scholar

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Volume5, Issue4

November 1958

Pages 249-251

Evaluation of Some Trypanostatic Agents by Means of Herpetomonas culicidarum

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Evaluation of Some Trypanostatic Agents by Means of Herpetomonas culicidarum

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