Original Article
Preserved Capillary Density of Dorsal Finger Skin in Treated Hypertensive Patients with or without Type 2 Diabetes
JEROME AELLEN,
AMIN DABIRI,
ABIGAEL HEIM, LUCAS LIAUDET, MICHEL BURNIER, JUAN RUIZ,
FRANÇOIS FEIHL, BERNARD WAEBER,
JEROME AELLEN
Division de Physiopathologie Clinique
These authors have equally contributed to the study.
Search for more papers by this authorAMIN DABIRI
Division de Physiopathologie Clinique
These authors have equally contributed to the study.
Search for more papers by this authorJUAN RUIZ
Service d’Endocrinoloige, Diabétologie et Métabolisme, Centre Hospitalier Universtaire Vaudois and Université de Lausanne, Lausanne, Switzerland
Search for more papers by this authorJEROME AELLEN,
AMIN DABIRI,
ABIGAEL HEIM, LUCAS LIAUDET, MICHEL BURNIER, JUAN RUIZ,
FRANÇOIS FEIHL, BERNARD WAEBER,
JEROME AELLEN
Division de Physiopathologie Clinique
These authors have equally contributed to the study.
Search for more papers by this authorAMIN DABIRI
Division de Physiopathologie Clinique
These authors have equally contributed to the study.
Search for more papers by this authorJUAN RUIZ
Service d’Endocrinoloige, Diabétologie et Métabolisme, Centre Hospitalier Universtaire Vaudois and Université de Lausanne, Lausanne, Switzerland
Search for more papers by this authorProf. François Feihl, PPA, BH10-701, CHUV, CH-1011 Lausanne, Switzerland. E-mail:[email protected]
Previous presentation: Oral communication at the meeting of the European Society of Hypertension, June 20, 2011, Milano, Italy
Abstract
Please cite this paper as: Aellen J, Dabiri A, Heim A, Liaudet L, Burnier M, Ruiz J, Feihl F, Waeber B. Preserved capillary density of dorsal finger skin in treated hypertensive patients with or without type 2 diabetes. Microcirculation 19: 554–562, 2012.
Objectives: Capillary rarefaction is a hallmark of untreated hypertension. Recent data indicate that rarefaction may be reversed by antihypertensive treatment in nondiabetic hypertensive patients. Despite the frequent association of diabetes with hypertension, nothing is known on the capillary density of treated diabetic patients with hypertension.
Methods: We enrolled 21 normotensive healthy, 25 hypertensive only, and 21 diabetic (type 2) hypertensive subjects. All hypertensive patients were treated with a blocker of the renin-angiotensin system, and a majority had a home blood pressure ≤135/85 mmHg. Capillary density was assessed with videomicroscopy on dorsal finger skin and with laser Doppler imaging on forearm skin (maximal vasodilation elicited by local heating).
Results: There was no difference between any of the study groups in either dorsal finger skin capillary density (controls 101 ± 11 capillaries/mm2, nondiabetic hypertensive 99 ± 16, diabetic hypertensive 96 ± 18, p > 0.5) or maximal blood flow in forearm skin (controls 666 ± 114 perfusion units, nondiabetic hypertensive 612 ± 126, diabetic hypertensive 620 ± 103, p > 0.5).
Conclusions: Irrespective of the presence or not of type 2 diabetes, capillary density is normal in hypertensive patients with reasonable control of blood pressure achieved with a blocker of the renin-angiotensin system.
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