Cord blood banking and transplantation at the Mexican Institute of Social Security: the first 5 years
Angel Guerra-Marquez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorBarbara Novelo-Garza
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorAraceli Malagón-Martínez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorAlejandro Limon-Flores
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorFernando Luna-Bautista
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorLuis Juan-Shum
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorInes Montero-Ponce
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorElizabeth Sanchez-Valle
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorKarina Peñaflor
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorMaria Antonieta Vélez-Ruelas
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorYanin Romero-Juárez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorHector Mayani
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorAngel Guerra-Marquez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorBarbara Novelo-Garza
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorAraceli Malagón-Martínez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorAlejandro Limon-Flores
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorFernando Luna-Bautista
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorLuis Juan-Shum
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorInes Montero-Ponce
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorElizabeth Sanchez-Valle
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorKarina Peñaflor
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorMaria Antonieta Vélez-Ruelas
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorYanin Romero-Juárez
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorHector Mayani
From the Umbilical Cord Blood Bank and the Department of Pediatric Hematology, La Raza Medical Center; the Department of Hematology, Pediatrics Hospital and the Department of Hematology, Medical Specialties Hospital, Siglo XXI Medical Center; the Department of Pediatrics, Carlos MacGregor Hospital; the Oncology Research Unit, Oncology Hospital, Siglo XXI Medical Center, Mexican Institute of Social Security, Mexico City, Mexico; and the Department of Hematology, Medical Specialties Hospital, Mexican Institute of Social Security, Puebla City, Mexico.
Search for more papers by this authorThis study was supported by Grant 7204 from the National Council of Science and Technology (CONACYT, Mexico) and Grant 2005/2/I/365 from the Health Research Council of the Mexican Institute of Social Security (IMSS). Core support was provided by the IMSS Medical Division.
Abstract
BACKGROUND: In January 2005, the Cord Blood Bank (CBB) at the Mexican Institute of Social Security initiated activities. Herein, we describe the experience generated during this period (January 1, 2005-December 31, 2009).
STUDY DESIGN AND METHODS: Good manufacturing practices and standard operating procedures were used to address donor selection, as well as umbilical cord blood (UCB) collection, processing, and cryopreservation. Based mainly on HLA and nucleated cell content, specific UCB units were thawed, processed, and released for transplantation.
RESULTS: A total of 589 UCB units were stored, representing 54% of the total number of units collected. Forty-eight units (8.14% of the stored units) were released for transplantation of 36 patients. Twenty-six patients (72% of cases) corresponded to patients with acute leukemia, five (14%) to patients with marrow failure, and the rest (five; 14%) to patients with hemoglobinopathies and other syndromes. The median number of nucleated cells infused per patient was 6.71 × 107/kg and the median number of CD34+ cells was 4.8 × 105/kg. Current engraftment data indicate that engraftment occurred in 56%, and no engraftment in 44%, of cases. Engraftment was more frequent (59%) in patients that received more than 3 × 107 total nucleated cells (TNCs)/kg body weight, than in those receiving fewer than 3 × 107 TNCs/kg (40%). Myeloid engraftment was observed 7 to 54 days posttransplant (median, 23 days), whereas platelet engraftment was detected on Days 12 to 87 posttransplant (median, 38 days). To date, the disease-free survival rate was 41% and the overall survival was 47%, with survival periods of 126 to 1654 days.
CONCLUSION: Although the experience presented herein is still limited and the period of analysis is still short, the results obtained during these 5 years are encouraging.
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