Cell therapy for epilepsy using GABAergic neural progenitors
Address correspondence to Scott C. Baraban, Ph.D., Box 0112, 513 Parnassus Avenue, University of California, San Francisco, CA 94143, U.S.A. E-mail: [email protected]
Summary
Cell transplantation may repair neural circuits in the epileptic brain. Grafted cells should disperse, migrate, and functionally integrate. Generation of inhibitory interneurons with these abilities could be therapeutic in a condition of abnormal neuronal hyperexcitability, that is, epilepsy. This review discusses recent efforts to isolate and transplant interneuron precursor cells derived from the medial ganglionic eminence. For an expanded treatment of this topic see Jasper’s basic mechanisms of the epilepsies. 4th ed. (Noebels JL, Avoli M, Rogawski MA, Olsen RW, Delgado-Escueta AV, eds) published by Oxford University Press (available on the National Library of Medicine Bookshelf [NCBI] at http://www.ncbi.nlm.nih.gov/books).
