Distributed source modeling of language with magnetoencephalography: Application to patients with intractable epilepsy
Carrie R. McDonald
Department of Psychiatry
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Search for more papers by this authorThomas Thesen
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorDonald J. Hagler Jr
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Search for more papers by this authorChad Carlson
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorOrrin Devinksy
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorRubin Kuzniecky
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorWilliam Barr
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorLusineh Gharapetian
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Search for more papers by this authorAmy Trongnetrpunya
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorAnders M. Dale
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Neurosciences, University of California, San Diego, California, U.S.A.
Search for more papers by this authorEric Halgren
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Neurosciences, University of California, San Diego, California, U.S.A.
Search for more papers by this authorCarrie R. McDonald
Department of Psychiatry
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Search for more papers by this authorThomas Thesen
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorDonald J. Hagler Jr
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Search for more papers by this authorChad Carlson
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorOrrin Devinksy
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorRubin Kuzniecky
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorWilliam Barr
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorLusineh Gharapetian
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Search for more papers by this authorAmy Trongnetrpunya
Comprehensive Epilepsy Center, Department of Neurology, New York University, New York, New York, U.S.A.
Search for more papers by this authorAnders M. Dale
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Neurosciences, University of California, San Diego, California, U.S.A.
Search for more papers by this authorEric Halgren
Multimodal Imaging Laboratory, University of California, San Diego, California, U.S.A.
Department of Radiology and
Neurosciences, University of California, San Diego, California, U.S.A.
Search for more papers by this authorSummary
Purpose: To examine distributed patterns of language processing in healthy controls and patients with epilepsy using magnetoencephalography (MEG), and to evaluate the concordance between laterality of distributed MEG sources and language laterality as determined by the intracarotid amobarbital procedure (IAP).
Methods: MEG was performed in 10 healthy controls using an anatomically constrained, noise-normalized distributed source solution (dynamic statistical parametric map, dSPM). Distributed source modeling of language was then applied to eight patients with intractable epilepsy. Average source strengths within temporoparietal and frontal lobe regions of interest (ROIs) were calculated, and the laterality of activity within ROIs during discrete time windows was compared to results from the IAP.
Results: In healthy controls, dSPM revealed activity in visual cortex bilaterally from ∼80 to 120 ms in response to novel words and sensory control stimuli (i.e., false fonts). Activity then spread to fusiform cortex ∼160–200 ms, and was dominated by left hemisphere activity in response to novel words. From ∼240 to 450 ms, novel words produced activity that was left-lateralized in frontal and temporal lobe regions, including anterior and inferior temporal, temporal pole, and pars opercularis, as well as bilaterally in posterior superior temporal cortex. Analysis of patient data with dSPM demonstrated that from 350 to 450 ms, laterality of temporoparietal sources agreed with the IAP 75% of the time, whereas laterality of frontal MEG sources agreed with the IAP in all eight patients.
Discussion: Our results reveal that dSPM can unveil the timing and spatial extent of language processes in patients with epilepsy and may enhance knowledge of language lateralization and localization for use in preoperative planning.
Supporting Information
Figure S1. Visual semantic judgment task. SOA, stimulus onset asynchrony.
Table S1. Relationship between IAP and MEG language laterality from 350 to 450 ms.
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