Volume 47, Issue 11 pp. 1958-1962

Mesial Temporal Inhibition in a Patient with Deep Brain Stimulation of the Anterior Thalamus for Epilepsy

Dominik Zumsteg,

Dominik Zumsteg

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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Andres M. Lozano,

Andres M. Lozano

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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Richard A. Wennberg,

Richard A. Wennberg

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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Dominik Zumsteg,

Dominik Zumsteg

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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Andres M. Lozano,

Andres M. Lozano

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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Richard A. Wennberg,

Richard A. Wennberg

Krembil Neuroscience Centre, Toronto Western Hospital, University of Toronto, Toronto, Canada

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First published: 26 October 2006

https://doi.org/10.1111/j.1528-1167.2006.00824.x

Citations: 73

Address correspondence and reprint requests to Dr. Dominik Zumsteg, M.D., Krembil Neuroscience Centre, Toronto Western Hospital, 5W-425, University of Toronto, 399 Bathurst Street, Toronto, ON, M5T 2S8, Canada. E-mail: [email protected]

Dr. Lozano and Dr. Wennberg are consultants for Medtronic, Inc.

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Abstract

Summary: We investigated the electrophysiological effects of high-frequency anterior thalamic deep brain stimulation using intracerebral mesial and lateral temporal depth electrodes in a patient with intractable focal epilepsy. Monopolar and bipolar stimulation delivered to the thalamic anterior nucleus using the programmable ITREL II stimulation device led to a significant decrease of cross power spectral density and a nonsignificant decrease of coherence in ipsilateral hippocampal structures. No such effect was found in lateral temporal or contralateral sites. The hippocampal inhibition was clearly related to the voltage (≥7 V) and frequency (≥70 Hz) of the thalamic stimulus and occurred with a delay of approximately 60 s after stimulus onset.

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Volume47, Issue11

November 2006

Pages 1958-1962

Mesial Temporal Inhibition in a Patient with Deep Brain Stimulation of the Anterior Thalamus for Epilepsy

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Mesial Temporal Inhibition in a Patient with Deep Brain Stimulation of the Anterior Thalamus for Epilepsy

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