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Selenium in Uremia
Mario Bonomini,
Alberto Albertazzi,
Corresponding Author
Mario Bonomini
Department of Nephrology and Dialysis, University of Chieti, Chieti, Italy
2 Institute of Nephrology, S. Camillo De Lellis University Hospital, Via C. Forlanini, 1–66100 Chieti, Italy.Search for more papers by this authorAlberto Albertazzi
Department of Nephrology and Dialysis, University of Chieti, Chieti, Italy
Search for more papers by this authorMario Bonomini,
Alberto Albertazzi,
Corresponding Author
Mario Bonomini
Department of Nephrology and Dialysis, University of Chieti, Chieti, Italy
2 Institute of Nephrology, S. Camillo De Lellis University Hospital, Via C. Forlanini, 1–66100 Chieti, Italy.Search for more papers by this authorAlberto Albertazzi
Department of Nephrology and Dialysis, University of Chieti, Chieti, Italy
Search for more papers by this authorAbstract
Abstract: The importance of selenium as an essential trace element for man has been increasingly recognized during the last several years. Selenium deficiency has been associated with cases of congestive cardiomyopa-thy, skeletal myopathy, anemia, enhanced cancer risk, elevated incidence of cardiovascular disease, immune system alterations, hair and nail changes, and abnormalities in thyroid hormone metabolism. These symptoms are frequently present in chronic uremic patients. Nevertheless, the prevalence and significance of selenium deficiency in the uremic syndrome is still not clearly defined. This article reviews the selenium status in chronic uremic patients, the supposed pathogenetic mechanisms of selenium disturbance in uremia, and the possible role of selenium deficiency on some uremic abnormalities.
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