Address correspondence to Antonio Torrelo, M.D., Department of Dermatology, Hospital del Niño Jesús, Menéndez Pelayo 65, 28009 Madrid, Spain, or e-mail: [email protected].

Read the full text

About

PDF

Tools

Share a link

Email
Wechat
Bluesky

Abstract

Abstract: We report two newborns with a widespread cutaneous eruption consisting of discrete papules which evolved into vesicles, pustules, crusts, and ulcers. These healed over a 2-week period with scarring. Histopathology showed three main features—histiocytic granulomas, neutrophilic infiltration, and transepidermal elimination of degenerated collagen and debris through hair follicles. Both patients had congenital immunodeficiency. This skin condition of the newborn, with distinct clinical and histopathologic features, is a manifestation of immunodeficiency that has not been previously described.

References

1 Ballow M. Primary immunodeficiency disorders: antibody deficiency. J Allergy Clin Immunol 2002; 109: 581–591.
10.1067/mai.2002.122466
CAS PubMed Web of Science® Google Scholar
2 Gamo Villegas R, Sopena Barona J, Guerra Tapia A et al. Pustular generalized perforating granuloma annulare. Br J Dermatol 2003; 149: 866–868.
10.1046/j.1365-2133.2003.05655.x
CAS PubMed Web of Science® Google Scholar
3 Huerter CJ, Bass J, Bergfeld WF et al. Perforating granuloma annulare in a patient with acquired immunodeficiency syndrome. Immunohistologic evaluation of the cellular infiltrate. Arch Dermatol 1987; 123: 1217–1220.
10.1001/archderm.1987.01660330128025
CAS PubMed Web of Science® Google Scholar
4 Nunez M, Miralles ES, Del Olmo N et al. Perforating granuloma annulare and HIV. Acta Derm Venereol 1995; 75: 407.
CAS PubMed Web of Science® Google Scholar
5 Toro JR, Chu P, Yen TS et al. Granuloma annulare and human immunodeficiency virus infection. Arch Dermatol 1999; 135: 1341–1346.
10.1001/archderm.135.11.1341
CAS PubMed Web of Science® Google Scholar
6 Cohen PR. Granuloma annulare: a mucocutaneous condition in human immunodeficiency virus-infected patients. Arch Dermatol 1999; 135: 1404–1407.
10.1001/archderm.135.11.1404
CAS PubMed Web of Science® Google Scholar
7 O'Moore EJ, Nandawni R, Uthayakumar S et al. HIV-associated granuloma annulare (HAGA): a report of six cases. Br J Dermatol 2000; 142: 1054–1056.
10.1046/j.1365-2133.2000.03501.x
CAS PubMed Web of Science® Google Scholar
8 Paul M, Cribier B, Heid E et al. Generalized granuloma annulare and drug-induced immunodeficiency. Ann Dermatol Venereol 2004; 131: 1051–1054.
10.1016/S0151-9638(04)93839-2
CAS PubMed Web of Science® Google Scholar
9 Kutukculer N, Tutuncuoglu S, Yilmaz D et al. Subcutaneous granuloma annulare and IgA-IgG2 deficiency. Turk J Pediatr 1998; 40: 279–281.
CAS PubMed Web of Science® Google Scholar
10 Fleming MG, Gewurz AT, Pearson RW. Caseating cutaneous granulomas in a patient with X-linked infantile hypogammaglobulinemia. J Am Acad Dermatol 1991; 24: 629–633.
10.1016/0190-9622(91)70097-L
PubMed Web of Science® Google Scholar
11 Siegfried EC, Prose NS, Friedman NJ et al. Cutaneous granulomas in children with combined immunodeficiency. J Am Acad Dermatol 1991; 25: 761–766.
10.1016/S0190-9622(08)80965-6
CAS PubMed Web of Science® Google Scholar
12 Paller AS, Massey RB, Curtis MA et al. Cutaneous granulomatous lesions in patients with ataxia-telangiectasia. J Pediatr 1991; 119: 917–922.
10.1016/S0022-3476(05)83043-4
CAS PubMed Web of Science® Google Scholar
13 Torrelo A, Mediero IG, Zambrano A. Caseating cutaneous granulomas in a child with common variable immunodeficiency. Pediatr Dermatol 1995; 12: 170–173.
10.1111/j.1525-1470.1995.tb00147.x
PubMed Web of Science® Google Scholar
14 Mitra A, Pollock B, Gooi J et al. Cutaneous granulomas associated with primary immunodeficiency disorders. Br J Dermatol 2005; 153: 194–199.
10.1111/j.1365-2133.2005.06619.x
CAS PubMed Web of Science® Google Scholar
15 Pujol RM, Nadal C, Tarberner R et al. Cutaneous granulomatous lesions in common variable immunodeficiency: complete resolution after intravenous immunoglobulins. Dermatology 1999; 198: 156–158.
10.1159/000018093
CAS PubMed Web of Science® Google Scholar
16 Joshi RK, Al Asiri RH, Haleem A et al. Cutaneous granuloma with ataxia telangiectasia – a case report and review of the literature. Clin Exp Dermatol 1993; 18: 458–461.
10.1111/j.1365-2230.1993.tb02251.x
CAS PubMed Web of Science® Google Scholar
17 Cohen LE, Tanner DJ, Scaefer HG et al. Common and uncommon cutaneous finding in patients with ataxia telangiectasia. J Am Acad Dermatol 1984; 10: 431–438.
10.1016/S0190-9622(84)80089-4
CAS PubMed Web of Science® Google Scholar
18 Thatayatikom A, Thatayatikom S, White AJ. Infliximab treatment for severe granulomatous disease in common variable immunodeficiency: a case report and review of the literature. Ann Allergy Asthma Immunol 2005; 95: 293–300.
10.1016/S1081-1206(10)61228-8
PubMed Web of Science® Google Scholar
19 Lin JH, Liebhaber M, Roberts RL et al. Etanercept treatment of cutaneous granulomas in common variable immunodeficiency. J Allergy Clin Immunol 2006; 117: 878–882.
10.1016/j.jaci.2006.01.034
CAS PubMed Web of Science® Google Scholar

Citing Literature

Volume24, Issue3

May/June 2007

Pages 211-215

Perforating Neutrophilic and Granulomatous Dermatitis of the Newborn—A Clue to Immunodeficiency

Abstract

References

Citing Literature

References

Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Perforating Neutrophilic and Granulomatous Dermatitis of the Newborn—A Clue to Immunodeficiency

Abstract

References

Citing Literature

References

Related

Information