Over Expression of RhoA is Associated with Progression in Invasive Breast Duct Carcinoma
Li Ma MD, Yue-ping Liu MD,
Cui-zhi Geng MD, Xiao-ling Wang MD, Yong-jun Wang BSc, Xiang-hong Zhang MD,
Yue-ping Liu MD
Pathology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
Search for more papers by this authorXiang-hong Zhang MD
Department of Laboratory of Experimental Pathology, Institute of Basic Medical University Shijiazhuang, Hebei Province, China
Search for more papers by this authorLi Ma MD, Yue-ping Liu MD,
Cui-zhi Geng MD, Xiao-ling Wang MD, Yong-jun Wang BSc, Xiang-hong Zhang MD,
Yue-ping Liu MD
Pathology, the Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China
Search for more papers by this authorXiang-hong Zhang MD
Department of Laboratory of Experimental Pathology, Institute of Basic Medical University Shijiazhuang, Hebei Province, China
Search for more papers by this authorAddress correspondence and reprint requests to: Xiang-hong Zhang, MD, Department of Laboratory of Experimental Pathology, Institute of Basic Medical University, No. 361, Zhongshan East Rd, Shijiazhuang, 050017, China, or e-mail: [email protected].

References
- 1 Kimmelman AC, Hezel AF, Aguirre AJ, et al. Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci USA 2008; 105: 19372–7.
- 2 Kamai T, Tsujii T, Arai K, et al. Significant association of Rho/ROCK pathway with invasion and metastasis of bladder cancer. Clin Cancer Res 2003; 9: 2632–41.
- 3 Faried A, Nakajima M, Sohda M, et al. Correlation between RhoA overexpression and tumour progression in esophageal squamous cell carcinoma. Eur J Surg Oncol 2005; 31: 410–4.
- 4 Elston CW, Ellis IO. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology 1991; 19: 403–10.
- 5 Mon NN, Kokuryo T, Hamaguchi M. Inflammation and tumor progression: a lesson from TNF-alpha-dependent FAK signaling in cholangiocarcinoma. Methods Mol Biol 2009; 512: 279–93.
- 6 Golubovskaya VM, Kweh FA, Cance WG., et al. Focal adhesion kinase and cancer. Histol Histopathol 2009; 24: 503–10.
- 7 Katoh K, Kano Y, Ookawara S. Rho-kinase dependent organization of stress fibers and focal adhesions in cultured fibroblasts. Genes Cells 2007; 12: 623–38.
- 8 Miyazaki T, Kato H, Nakajima M, et al. FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. Br J Cancer 2003; 89: 140–5.
- 9 Horiuchi A, Kikuchi N, Osada R, et al. Overexpression of RhoA enhances peritoneal dissemination: RhoA suppression with lovastatin may be useful for ovarian cancer. Cancer Sci 2008; 99: 2532–9.
- 10 Iiizumi M, Bandyopadhyay S, Pai SK, et al. RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res 2008; 68: 7613–20.
- 11 Zhao L, Wang H, Li J, et al. Overexpression of Rho GDP-dissociation inhibitor alpha is associated with tumor progression and poor prognosis of colorectal cancer. J Proteome Res 2008; 7: 3994–4003.
- 12 Lu Q, Longo FM, Zhou H, et al. Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem 2009; 16: 1355–65.