15th International Symposium on Cells of the Hepatic Sinusoid, 2010
Laurie D. DeLeve
Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorHartmut Jaeschke
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
Search for more papers by this authorVijay K. Kalra
Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorKinji Asahina
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorDavid A. Brenner
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Department of Medicine, University of California, San Diego, CA, USA
Search for more papers by this authorHidekazu Tsukamoto
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Search for more papers by this authorLaurie D. DeLeve
Division of Gastrointestinal and Liver Diseases, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorHartmut Jaeschke
Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, KS, USA
Search for more papers by this authorVijay K. Kalra
Department of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorKinji Asahina
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Search for more papers by this authorDavid A. Brenner
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Department of Medicine, University of California, San Diego, CA, USA
Search for more papers by this authorHidekazu Tsukamoto
Southern California Research Center for ALPD and Cirrhosis and Department of Pathology, University of Southern California Keck School of Medicine, Los Angeles, CA, USA
Department of Veterans Affairs Greater Los Angeles Healthcare System, Los Angeles, CA, USA
Search for more papers by this authorAbstract
This is a meeting report of the presentations given at the 15th International Symposium on Cells of the Hepatic Sinusoid, held in 2010. The areas covered include the contributions of the various liver cell populations to liver disease, molecular and cellular targets involved in steatohepatitis, hepatic fibrosis and cancer and regenerative medicine. In addition to a review of the science presented at the meeting, this report provides references to recent literature on the topics covered at the meeting.
References
- 1 Miller AM, Horiguchi N, Jeong WI, Radaeva S, Gao B. Molecular mechanisms of alcoholic liver disease: innate immunity and cytokines. Alcohol Clin Exp Res 2011; 787–93.
- 2 Inokuchi S, Tsukamoto H, Liu Z, Brenner DA, Seki E. Toll-like receptor 4 induces alcoholic liver disease through bone marrow-derived and endogenous liver cells. Alcohol Clin Exp Stud 2010; 107: 844–9.
- 3 Teixeira-Clerc F, Belot MP, Manin S, et al. Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology 2010; 52: 1046–59.
- 4 Martinez-Clemente M, Ferre N, Titos E, et al. Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. Hepatology 2010; 52: 1980–91.
- 5 Aoyama T, Inokuchi S, Brenner DA, Seki E. CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice. Hepatology 52: 1390–400.
- 6 Ishikawa S, Ikejima K, Yamagata H, et al. CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice. J Hepatol 2011; doi:DOI: 10.1016/j.jhep.2010.08.022 [Epub ahead of print].
- 7 Miura K, Kodama Y, Inokuchi S, et al. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology 2010; 139: 323–34, e7.
- 8 Williams CD, Farhood A, Jaeschke H. Role of caspase-1 and interleukin-1beta in acetaminophen-induced hepatic inflammation and liver injury. Toxicol Appl Pharmacol 2010; 247: 169–78.
- 9 Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 2008; 88: 125–72.
- 10 Scholten D, Osterreicher CH, Scholten A, et al. Genetic labeling does not detect epithelial-to-mesenchymal transition of cholangiocytes in liver fibrosis in mice. Gastroenterology 2010; 139: 987–98.
- 11 Sommerfeld A, Reinehr R, Haussinger D. Bile acid-induced epidermal growth factor receptor activation in quiescent rat hepatic stellate cells can trigger both proliferation and apoptosis. J Biol Chem 2009; 284: 22173–83.
- 12 Aleffi S, Navari N, Delogu W, et al. The Mammalian target of rapamycin mediates the angiogenic effects of leptin in human hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 2011; doi:DOI: 10.?1152/?ajpgi.?00047.?2010 [Epub ahead of print].
- 13 Kawada N, Kristensen DB, Asahina K, et al. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem 2001; 276: 25318–23.
- 14 Oakley F, Teoh V, Ching ASG, et al. Angiotensin II activates I kappaB kinase phosphorylation of RelA at Ser 536 to promote myofibroblast survival and liver fibrosis. Gastroenterology 2009; 136: 2334–44, e1.
- 15 Hattori K, Dias S, Heissig B, et al. Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells. J Exp Med 2001; 193: 1005–14.
- 16 Grizzi F. Pirfenidone: a potential therapeutic option in the treatment of liver fibrosis. Clin Exp Pharmacol Physiol 2009; 36: 961–2.
- 17 Colina F, Lopez-Carreira M, Moreno E, et al. A clinopathologic review of 8 liver graft primary nonfunctions. Hepatogastroenterology 1995; 42: 212–21.
- 18 Sato Y, Murase K, Kato J, et al. Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone. Nat Biotechnol 2008; 26: 431–42.
- 19 Goessling W, North TE, Lord AM, et al. APC mutant zebrafish uncover a changing temporal requirement for wnt signaling in liver development. Dev Biol 2008; 320: 161–74.
- 20 Onitsuka I, Tanaka M, Miyajima A. Characterization and functional analyses of hepatic mesothelial cells in mouse liver development. Gastroenterology 2010; 138: 1525–35, e1–6.
- 21 Asahina K, Zhou B, Pu WT, Tsukamoto H. Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver. Hepatology 2010; 53: 983–95.
- 22 Matsumoto K, Miki R, Nakayama M, Tatsumi N, Yokouchi Y. Wnt9a secreted from the walls of hepatic sinusoids is essential for morphogenesis, proliferation, and glycogen accumulation of chick hepatic epithelium. Dev Biol 2008; 319: 234–47.
- 23 Tatsumi N, Miki R, Katsu K, Yokouchi Y. Neurturin-GFRalpha2 signaling controls liver bud migration along the ductus venosus in the chick embryo. Dev Biol 2007; 307: 14–28.
- 24 Wang Y, Cui CB, Yamauchi M, et al. Lineage restriction of human hepatic stem cells to mature fates is made efficient by tissue-specific biomatrix scaffolds. Hepatology 2011; 53: 293–305.
- 25 Ijpenberg A, Perez-Pomares JM, Guadix JA, et al. Wt1 and retinoic acid signaling are essential for stellate cell development and liver morphogenesis. Dev Biol 2007; 312: 157–70.
- 26 Sparks EE, Perrien DS, Huppert KA, Peterson T, Huppert SS. Defects in hepatic Notch signaling result in disruption of the communicating intrahepatic bile duct network in mice. Dis Model Mech 2011; 4: 359–67.
- 27 Nakamura T, Torimura T, Sakamoto M, et al. Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model. Gastroenterology 2007; 133: 91–107, e1.
- 28 Chung WS, Shin CH, Stainier D. Bmp2 signaling regulates the hepatic versus pancreatic fate decision. Dev Cell 2008; 15: 738–48.
- 29 Kato T, Ito Y, Hosono K, et al. Vascular endothelial growth factor receptor-1 signaling promotes liver repair through restoration of liver microvasculature after acetaminophen hepatotoxicity. Toxicol Sci 2010; 120: 218–29.
- 30 Saito R, Ishii Y, Ito R, et al. Transplantation of liver organoids in the omentum and kidney. Artif Organs 2011; 35: 80–3.
- 31 Morii M, Mezaki Y, Yamaguchi N, et al. Onset of apoptosis in the cystic duct during metamorphosis of a Japanese lamprey, Lethenteron reissneri. Anat Rec (Hoboken) 2010; 293: 1155–66.
- 32 Pritchard MT, Cohen JI, Roychowdhury S, Pratt BT, Nagy LE. Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice. J Hepatol 2010; 53: 655–62.
- 33 Wallace K, Marek CJ, Hoppler S, Wright MC. Glucocorticoid-dependent transdifferentiation of pancreatic progenitor cells into hepatocytes is dependent on transient suppression of WNT signalling. J Cell Sci 2010; 123 (Part 12): 2103–10.
- 34 Geraud C, Schledzewski K, Demory A, et al. Liver sinusoidal endothelium: a microenvironment-dependent differentiation program in rat including the novel junctional protein liver endothelial differentiation-associated protein-1. Hepatology 2010; 52: 313–26.
- 35 Li R, Oteiza A, Sorensen KK, et al. Role of Liver Sinusoidal Endothelial Cells and Stabilins in Elimination of Oxidized Low-Density Lipoproteins. Am J Physiol-Gastrointest Liver Physiology 2010; 300: G71–81.
- 36 Shintani T, Iwabuchi T, Soga T, et al. Cystathionine beta-synthase as a carbon monoxide-sensitive regulator of bile excretion. Hepatology 2009; 49: 141–50.
- 37 Menezes GB, Lee WY, Zhou H, et al. Selective down-regulation of neutrophil Mac-1 in endotoxemic hepatic microcirculation via IL-10. J Immunol 2009; 183: 7557–68.
- 38 Yeligar SM, Machida K, Tsukamoto H, Kalra VK. Ethanol augments RANTES/CCL5 expression in rat liver sinusoidal endothelial cells and human endothelial cells via activation of NF-kappa B, HIF-1 alpha, and AP-1. J Immunol 2009; 183: 5964–76.
- 39 Cogger VC, Mcnerney GP, Nyunt T, et al. Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol 2010; 171: 382–8.
- 40 Pak S, Kondo T, Nakano Y, et al. Platelet adhesion in the sinusoid caused hepatic injury by neutrophils after hepatic ischemia reperfusion. Platelets 2010; 21: 282–8.
- 41 Burlak C, Paris LL, Chihara RK, et al. The fate of human platelets perfused through the pig liver: implications for xenotransplantation. Xenotransplantation 2010; 17: 350–61.
- 42 Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell 2010; 140: 883–99.
- 43 Schiff ER, Ozden N. Hepatitis C and alcohol. Alcohol Res Health 2003; 27: 232–9.
- 44 Machida K, Tsukamoto H, Mkrtchyan H, et al. Toll-like receptor 4 mediates synergism between alcohol and HCV in hepatic oncogenesis involving stem cell marker Nanog. Proc Natl Acad Sci USA 2009; 106: 1548–53.
- 45 Inokuchi S, Aoyama T, Miura K, et al. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. Proc Natl Acad Sci USA 2010; 107: 844–9.
- 46 Arteta B, Lasuen N, Lopategi A, et al. Colon carcinoma cell interaction with liver sinusoidal endothelium inhibits organ-specific antitumor immunity through interleukin-1-induced mannose receptor in mice. Hepatology 2010; 51: 2172–82.
- 47 Khatib AM, Auguste P, Fallavollita L, et al. Characterization of the host proinflammatory response to tumor cells during the initial stages of liver metastasis. Am J Pathol 2005; 167: 749–59.
- 48 Illemann M, Bird N, Majeed A, et al. Two distinct expression patterns of urokinase, urokinase receptor and plasminogen activator inhibitor-1 in colon cancer liver metastases. Int J Cancer 2009; 124: 1860–70.
- 49 Cave M, Falkner KC, Ray M, et al. Toxicant-associated steatohepatitis in vinyl chloride workers. Hepatology 2010; 51: 474–81.
- 50 Takami T, Terai S, Yokoyama Y, et al. Human homologue of maid is a useful marker protein in hepatocarcinogenesis. Gastroenterology 2005; 128: 1369–80.
- 51 Wang H, Park O, Lafdil F, et al. Interplay of hepatic and myeloid signal transducer and activator of transcription 3 in facilitating liver regeneration via tempering innate immunity. Hepatology 2010; 51: 1354–62.
- 52 Zhong S, Machida K, Tsukamoto H, Johnson DL. Alcohol Induces RNA Polymerase III-dependent Transcription through c-Jun by Co-regulating TATA-binding Protein (TBP) and Brf1 Expression. J Biol Chem 2011; 286: 2393–401.
- 53 Elvevold K, Smedsrød B, Martinez I. The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity. Am J Physiol Gastrointest Liver Physiol 2007; 294: 391–400.
- 54 Higashi N, Imai K, Sato M, et al. Intralobular distribution of vitamin a-storing lipid droplets in hepatic stellate cells with special reference to polar bear and arctic fox. Comp Hepatol 2004; 3 (Suppl. 1): S16.
Citing Literature
