Clinical Physiology and Functional Imaging

Volume 32, Issue 4 pp. 288-295

Original Article

Changes in lung function of HIV-infected patients: a 4·5-year follow-up study

Ulrik Sloth Kristoffersen,

Corresponding Author

Ulrik Sloth Kristoffersen

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

Correspondence

Ulrik Sloth Kristoffersen, MD, PhD, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, KF-4011, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

E-mail: [email protected]

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Anne-Mette Lebech,

Anne-Mette Lebech

Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark

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Jann Mortensen,

Jann Mortensen

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

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Jan Gerstoft,

Jan Gerstoft

Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark

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Henrik Gutte,

Henrik Gutte

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

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Andreas Kjaer,

Andreas Kjaer

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

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Ulrik Sloth Kristoffersen,

Corresponding Author

Ulrik Sloth Kristoffersen

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

Correspondence

Ulrik Sloth Kristoffersen, MD, PhD, Department of Clinical Physiology, Nuclear Medicine & PET, Rigshospitalet, KF-4011, Blegdamsvej 9, DK-2100 Copenhagen, Denmark

E-mail: [email protected]

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Anne-Mette Lebech,

Anne-Mette Lebech

Department of Infectious Diseases, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark

Search for more papers by this author

Jann Mortensen,

Jann Mortensen

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Search for more papers by this author

Jan Gerstoft,

Jan Gerstoft

Department of Infectious Diseases, Copenhagen University Hospital, Copenhagen, Denmark

Search for more papers by this author

Henrik Gutte,

Henrik Gutte

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

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Andreas Kjaer,

Andreas Kjaer

Department of Clinical Physiology, Nuclear Medicine & PET, Copenhagen University Hospital, Copenhagen, Denmark

Cluster for Molecular Imaging, University of Copenhagen, Copenhagen, Denmark

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First published: 11 March 2012

https://doi.org/10.1111/j.1475-097X.2012.01124.x

Citations: 52

Data in part presented at: 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) September 12-15, 2009, San Francisco, CA.

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Summary

Objective

To investigate the development of lung function in HIV-infected patients.

Methods

In a prospective cohort study, 88 HIV-infected patients had a lung function test performed and 63 patients (72%) had their LFT repeated with a median follow-up period of 4·4 years. Forty-eight per cent were smokers, and at the re-examination, 97% were on combination antiretroviral therapy.

Results

Carbon monoxide diffusion capacity was reduced and decreased over time in both smokers and non-smokers. Alveolar volume decreased and forced vital capacity increased similarly in both smokers and non-smokers. No changes were observed in forced expiratory volume or peak flow, but smokers had reduced values compared with those of the non-smokers at both examinations. FEV1/FVC was reduced especially in smokers and declined in both smokers and non-smokers.

Conclusions

Carbon monoxide diffusion capacity is reduced in HIV-infected patients and seems to decline over time. Additionally, signs of obstructive lung disease are present in HIV-infected patients and seem to increase over time, although only modestly.

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Citing Literature

Volume32, Issue4

July 2012

Pages 288-295

Changes in lung function of HIV-infected patients: a 4·5-year follow-up study

Summary

Objective

Methods

Results

Conclusions

References

Citing Literature

References

Information

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Changes in lung function of HIV-infected patients: a 4·5-year follow-up study

Summary

Objective

Methods

Results

Conclusions

References

Citing Literature

References

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