Remodeling chromatin for senescence
Peter D. Adams,
Peter D. Adams
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Search for more papers by this authorPeter D. Adams,
Peter D. Adams
Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
Search for more papers by this authorPeter David Adams, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA. Tel.: 215 728 7108; fax: 215 728 3616; e-mail: [email protected]
Summary
Cellular senescence is an irreversible proliferation arrest that contributes to tumor suppression and, perhaps, tissue aging. Senescence is frequently accompanied by an increase in nuclear heterochromatin, which is thought to promote proliferation arrest. In this issue, Medrano and co-workers describe new insights into the protein complexes that regulate these changes in chromatin structure.
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