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Synergistic Action of Postsynaptic α-Adrenergic Receptor Stimulation on Vasoactive Intestinal Polypeptide-Induced Increases in Pineal N-Acetyltransferase Activity

Corresponding Author

A. Yuwiler

Neurobiochemistry Research Laboratory, Veterans Administration Medical Center, Brentwood; and Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine, University of California, Los Angeles, California, U.S.A.

Address correspondence and reprint requests to Dr. A. Yuwiler at Neurobiochemistry T-85, Veterans Administration Medical Center, Wilshire and Sawtelle Boulevards, Los Angeles, CA 90073, U.S.A.Search for more papers by this author

A. Yuwiler,

Corresponding Author

A. Yuwiler

First published: September 1987

https://doi.org/10.1111/j.1471-4159.1987.tb00965.x

Citations: 20

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Abstract

Abstract: The α-adrenergic agonists phenylephrine and methoxamine, at concentrations that have little effect on pineal N-acetyltransferase activity, markedly enhance stimulation of this enzyme by vasoactive intestinal polypeptide (VIP). This augmentation can be blocked by the α₁-adrenergic antagonists phenoxybenzamine and prazosin and, at 10 but not 1 μM, by the α₂-antagonist yohimbine. The time course for VIP stimulation is not altered by concomitant α-adrenergic stimulation. Augmented activity does not require concomitant α-adrenergic stimulation, but α-adrenergic agonists must be present for augmentation to be maintained. Phorbol 12, 13-diacetate or -dibutyrate but not 4a-phorbol can substitute for phenylephrine, a finding suggesting that protein kinase C is involved in the augmentation. These results are, in general, analogous to α-adrenergic magnification of N-acetyltransferase induction by β-adrenergic agonists.

Abbreviations used:

cAMP: cyclic AMP
ISO: L-isoproterenol
ME: methoxamine
NAT: serotonin N-acetyltransferase (acetyl-CoA:arylamine N-acetyltransferase
EC 2.3.1.5);PE: phenylephrine
VIP: vasoactive intestinal polypeptide

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Citing Literature

Volume49, Issue3

September 1987

Pages 806-811

Synergistic Action of Postsynaptic α-Adrenergic Receptor Stimulation on Vasoactive Intestinal Polypeptide-Induced Increases in Pineal N-Acetyltransferase Activity

Abstract

Abbreviations used:

References

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References

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Synergistic Action of Postsynaptic α-Adrenergic Receptor Stimulation on Vasoactive Intestinal Polypeptide-Induced Increases in Pineal N-Acetyltransferase Activity

Abstract

Abbreviations used:

References

Citing Literature

References

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