History of migraine and the risk of spontaneous cervical artery dissection
Corresponding Author
A Pezzini
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
the first two authors contributed equally to this work
Alessandro Pezzini, Clinica Neurologica, Università degli Studi di Brescia, P.le Spedali Civili 1, 25100 Brescia, Italia. Tel. +39 030 3995631/632 fax +39 030 3995027, e-mail [email protected]Search for more papers by this authorF Granella
the first two authors contributed equally to this work
Search for more papers by this authorM Grassi
Dipartimento di Scienze Mediche, Sezione di Statistica Medica ed Epidemiologia, Università degli Studi di Pavia, Pavia, Italy
Search for more papers by this authorC Bertolino
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorE Del Zotto
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorP Immovilli
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorE Bazzoli
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorA Padovani
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorC Zanferrari
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorCorresponding Author
A Pezzini
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
the first two authors contributed equally to this work
Alessandro Pezzini, Clinica Neurologica, Università degli Studi di Brescia, P.le Spedali Civili 1, 25100 Brescia, Italia. Tel. +39 030 3995631/632 fax +39 030 3995027, e-mail [email protected]Search for more papers by this authorF Granella
the first two authors contributed equally to this work
Search for more papers by this authorM Grassi
Dipartimento di Scienze Mediche, Sezione di Statistica Medica ed Epidemiologia, Università degli Studi di Pavia, Pavia, Italy
Search for more papers by this authorC Bertolino
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorE Del Zotto
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorP Immovilli
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorE Bazzoli
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorA Padovani
Clinica Neurologica, Università degli Studi di Brescia, Brescia,
Search for more papers by this authorC Zanferrari
Istituto di Neurologia, Dipartimento di Neuroscienze, Università di Parma, Parma and
Search for more papers by this authorAbstract
The pathophysiology of spontaneous cervical artery dissection (sCAD) is largely unknown. An association with migraine has been suggested, but not definitively proven. In the setting of a hospital-based prospective case-control study we assessed personal and family history of migraine in 72 patients with sCAD, 72 patients with cerebral infarct unrelated to a CAD (non-CAD) and 72 control subjects. Personal history of migraine was significantly associated to sCAD compared to non-CAD (59.7% vs. 30.6%; OR 3.14; 95% CI 1.41–7.01) and controls (18.1%; OR 7.41; 95% CI 3.11–17.64). As opposed to migraine with aura, migraine without aura was significantly more frequent among sCAD than among non-CAD (56.9% vs. 25.0%; OR 3.91; 95% CI 1.71–8.90) and controls (12.5%; OR 9.84; 95% CI 3.85–25.16). Similar results were observed when the frequencies of family history of migraine were compared. These findings are consistent with the hypothesis that migraine may represent a predisposing condition for sCAD.
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