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Acute Graft-Versus-Host Disease of the Large Intestine after Bone Marrow Transplantation

Corresponding Author

Jun-ichi HARUTA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

Address for reprint requests : Jun-ichi HARUTA, Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, 3-35 Michishita-cho, Nakamura-ku, Nagoya 453, Japan.Search for more papers by this author

Kazuo KUSUGAMI,

Kazuo KUSUGAMI

First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan

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Takeo YAMAGUCHI,

Takeo YAMAGUCHI

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Masafumi ITO,

Masafumi ITO

Department of Pathology, Nagoya University School of Medicine, Aichi, Japan

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Yuji OKA,

Yuji OKA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Atsuhiko KUSAKABE,

Atsuhiko KUSAKABE

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Nobuhiko TAKEDA,

Nobuhiko TAKEDA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Kazuo NOBATA,

Kazuo NOBATA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Hidehiko SAITO,

Hidehiko SAITO

First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan

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Jun-ichi HARUTA,

Corresponding Author

Jun-ichi HARUTA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

Kazuo KUSUGAMI,

Kazuo KUSUGAMI

First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan

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Takeo YAMAGUCHI,

Takeo YAMAGUCHI

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Masafumi ITO,

Masafumi ITO

Department of Pathology, Nagoya University School of Medicine, Aichi, Japan

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Yuji OKA,

Yuji OKA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Atsuhiko KUSAKABE,

Atsuhiko KUSAKABE

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Nobuhiko TAKEDA,

Nobuhiko TAKEDA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Kazuo NOBATA,

Kazuo NOBATA

Department of Gastroenterology, Japanese Red Cross Nagoya First Hospital, Aichi, Japan

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Hidehiko SAITO,

Hidehiko SAITO

First Department of Internal Medicine, Nagoya University School of Medicine, Aichi, Japan

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First published: 21 December 2007

https://doi.org/10.1111/j.1443-1661.1997.tb00473.x

Citations: 1

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Abstract

Abstract: A 13-year old male with acute lymphocytic leukemia was admitted to our hospital for bone marrow transplantation (BMT). Lower abdominal pain and bloody diarrhea developed during the fourth post-BMT week. Colonoscopy revealed edematous mucosa, erosions and multiple irregular ulcers in the rectum and sigmoid colon. Histologically, multiple apoptotic lesions were recognizable in the crypt basement membrane. Most infiltrating lymphoid cells were mature memory T lymphocytes bearing LFA-la-, CD43 and CD45RO antigens. HLA-DR and ICAM-1 immunostaining was seen on the vascular endothelium and the epithelium stained positively for HLA-DR antigens.

References

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Volume9, Issue2

April 1997

Pages 132-135

Acute Graft-Versus-Host Disease of the Large Intestine after Bone Marrow Transplantation

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Acute Graft-Versus-Host Disease of the Large Intestine after Bone Marrow Transplantation

Abstract

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