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Autoantibodies and CD5⁺ B cells in childhood onset immune thrombocytopenic purpura

Corresponding Author

HIDEAKI IYORI

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan.Search for more papers by this author

KOHJI FUJISAWA,

KOHJI FUJISAWA

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

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JUN-ICHI AKATSUKA,

JUN-ICHI AKATSUKA

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

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HIDEAKI IYORI,

Corresponding Author

HIDEAKI IYORI

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

Department of Pediatrics, Jikei University School of Medicine, 3-25-8 Nishi-shinbashi, Minato-ku, Tokyo 105, Japan.Search for more papers by this author

KOHJI FUJISAWA,

KOHJI FUJISAWA

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

Search for more papers by this author

JUN-ICHI AKATSUKA,

JUN-ICHI AKATSUKA

Department of Pediatrics, Jikei University School of Medicine, Nishi-shinbashi, Minato-ku, Tokyo, Japan

Search for more papers by this author

First published: June 1995

https://doi.org/10.1111/j.1442-200X.1995.tb03323.x

Citations: 4

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Abstract

We evaluated platelet associated immunoglobulin (PaIg) G, PaIgM, platelet associated autoantibodies to platelet glycoprotein IIb/IIIa (Pa-GPIIb/IIIa), the percentage of CD5⁺ B cells and the amount of platelet-bound anti-GPIIb/IIIa monoclonal antibody (mAb) in the peripheral blood of 29 patients with childhood onset chronic immune thrombocytopenic purpura (c-ITP). The percentage of CD5⁺ B cells ranged from 2 to 8% (4.7 ± 2.0) in control patients and 1 to 18% (6.2 ± 4.2) in the ITP patients. There was no overall significant difference between the two groups, but the percentage of CD5⁺ B cells in six of the ITP patients was higher than the mean + 2 s.d. of the controls. There was a significant correlation between the percentage of CD5⁺ B cells and PaIgM (y = 1.73x + 13.4, r = 0.40, P < 0.05). This finding is the basis for the speculation that CD5⁺ B cells may play an important role in the production of PaIgM in vivo. There was no correlation between the amounts of PaIgG and Pa-GPIIb/IIIa. This suggests that the amount of PaIgG does not accurately reflect of the amount of Pa-GPIIb/IIIa. Furthermore, we have demonstrated that autoantibodies to GPIIb/IIIa are directed to more than one epitope.

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Volume37, Issue3

June 1995

Pages 325-330

Autoantibodies and CD5⁺ B cells in childhood onset immune thrombocytopenic purpura

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Autoantibodies and CD5+ B cells in childhood onset immune thrombocytopenic purpura

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Autoantibodies and CD5⁺ B cells in childhood onset immune thrombocytopenic purpura