Primary gastric Ki-1 positive anaplastic large cell lymphoma: A report of two cases
Corresponding Author
Naoyoshi Mori
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Naoyoshi Mori, MD, First Department of Pathology, Nagoya University, School of Medicine, 65 Tsuruma-cho, Showaku, Nagoya 466, Japan.Search for more papers by this authorYasushi Yatabe
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Search for more papers by this authorKuniyuki Oka
Section of Hospital Laboratory Hospital, National Institute of Radiological Sciences, Chiba
Search for more papers by this authorTomoyuki Yokose
Division of Clinical Pathology and Internal Medicine, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo
Search for more papers by this authorTatsuya Ishido
Internal Medicine, National Cancer Center Hospital, Tokyo
Search for more papers by this authorMasanori Kikuchi
Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
Search for more papers by this authorJunpei Asai
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Search for more papers by this authorCorresponding Author
Naoyoshi Mori
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Naoyoshi Mori, MD, First Department of Pathology, Nagoya University, School of Medicine, 65 Tsuruma-cho, Showaku, Nagoya 466, Japan.Search for more papers by this authorYasushi Yatabe
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Search for more papers by this authorKuniyuki Oka
Section of Hospital Laboratory Hospital, National Institute of Radiological Sciences, Chiba
Search for more papers by this authorTomoyuki Yokose
Division of Clinical Pathology and Internal Medicine, Tokyo Metropolitan Tama Geriatric Hospital, Tokyo
Search for more papers by this authorTatsuya Ishido
Internal Medicine, National Cancer Center Hospital, Tokyo
Search for more papers by this authorMasanori Kikuchi
Department of Pathology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan
Search for more papers by this authorJunpei Asai
First Department of Pathology, Nagoya University, School of Medicine, Nagoya
Search for more papers by this authorAbstract
Two cases with primary gastric Ki-1 positive anaplastic large cell lymphoma are presented. Morphologic features of both cases involved pleomorphism of the neoplastic cells, fibrosis and lymphatic infiltration. The neoplastic cells in both cases were positive for BerH2 (CD30), LCA(CD45), lysozyme and alpha-1-antitrypsin (α1-AT). In additional case, the neoplastic cells were additionally positive for MAC387 and (α1,-antichymotrypsin (α,-ACT). The neoplastic cells in these cases were negative for L26(CD20), UCHL-1 (CD45RO), DAKO CD3 and epithelial membrane antigen (EMA). According to the results of the phenotypic studies, the authors consider that the neoplastic cells have some of the features of histiocytes.
Both patients at 2 and 8 years after surgery without chemotherapy are disease free. This lymphoma is well known to be frequently misdiagnosed as undifferentiated carcinoma. Although rare in occurrence, recognition of this primary lymphoma in the stomach has a significant clinical implication, as the authors consider that its prognosis might be better than undifferentiated carcinoma of the stomach.
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