Periodic Leg Movements in Sleep with Restless Legs Syndrome: Effect of Clonazepam Treatment
Corresponding Author
Jun Horiguchi M.D., Ph.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Department of Neuropsychiatry, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791–02, Japan.Search for more papers by this authorYasushi Inami M.D., Ph.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorAkira Sasaki M.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorOhichi Nishimatsu M.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorTsuruhei Sukegawa M.D, Ph. D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorCorresponding Author
Jun Horiguchi M.D., Ph.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Department of Neuropsychiatry, Ehime University School of Medicine, Shitsukawa, Shigenobu-cho, Onsen-gun, Ehime 791–02, Japan.Search for more papers by this authorYasushi Inami M.D., Ph.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorAkira Sasaki M.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorOhichi Nishimatsu M.D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorTsuruhei Sukegawa M.D, Ph. D
Department of Neuropsychiatry, Ehime University School of Medicine, Ehime
Search for more papers by this authorAbstract
Abstract: Fifteen patients with restless legs syndrome underwent whole-night polysomno-graphic recordings before and during clonazepam treatment. The treatment with 0.5 to 1.5 mg clonazepam improved subjective complaints of all the 15: patients. All the patients presented periodic leg movements on the polysomnograms before the treatment. The clonazepam treatment significantly decreased the total numbem of leg movements and the numbers of leg movements per hour without affecting the mean intermovement interval.
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