Distinguishing Acute and Tardive Akathisia by Monitoring Microvibration: A Pilot Study
Corresponding Author
Tadashi Nishikawa M.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Seiwakai Nishikawa Hospital, Hamada
Department of Pharmacology, Kurume University School of Medicine, Asahicho 67, Kurume 830, Japan.Search for more papers by this authorHiroo Kuwahara
Computer Center for Medical Research, Kurume University School of Medicine, Kurume
Search for more papers by this authorAkira Tsuda Ph.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Search for more papers by this authorMasatoshi Tanaka M.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Search for more papers by this authorCorresponding Author
Tadashi Nishikawa M.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Seiwakai Nishikawa Hospital, Hamada
Department of Pharmacology, Kurume University School of Medicine, Asahicho 67, Kurume 830, Japan.Search for more papers by this authorHiroo Kuwahara
Computer Center for Medical Research, Kurume University School of Medicine, Kurume
Search for more papers by this authorAkira Tsuda Ph.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Search for more papers by this authorMasatoshi Tanaka M.D
Department of Pharmacology, Kurume University School of Medicine, Kurume
Search for more papers by this authorAbstract
Abstract: One acute and one tardive akathisia patients, respectively, and 10: neuroleptic-treated schizophrenic patients were injected with biperiden 5: mg or saline and the response to anticholinergics was monitored by microvibration (MV) as an indicator of muscle tonus. These data were subjected to the Fast Fourier Transform and an averaged power spectrum was computed. The biperiden injection markedly reduced the power spectral values of MV in acute akathisia. In contrast with acute akathisia, the biperiden injection sigdlcantly increased the power spectral values of MV in tardive akathisia. The subjective feelings of akathisia patients were parallel to the power spectral values of MV. Control patients were not aflected by such treatment. The present findings show that the subjective symptoms of akathisia can be well defined by the objective, differential response to anticholinergics in a manner similar to the visible extrapyramidal symptoms (dystonia, dyskinesia) induced by neuroleptics.
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