Acute Effect of Potassium Penicillin G on Experimental Focal Epilepsy
Summary
Intraperitoneal PC injections could produce secondarily generalized seizures in both the experimental models of focal epilepsy: amygdaloid kindling models and KA-in-duced limbic seizure models. In the controls, a large amount of PC induced bilateral cortical epileptiform discharges but not in the limbic structures. The epileptic foci induced by the KA injection are more sensitive to PC than the foci induced by kindling.