Volume 41, Issue 3 pp. 516-518
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Acute Effect of Potassium Penicillin G on Experimental Focal Epilepsy

Shigeya Tanaka M.D.

Shigeya Tanaka M.D.

Department of Neurosurgery, Asahikawa Medical College, Asahikawa

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Mitsunobu Kaijima M.D.

Mitsunobu Kaijima M.D.

Department of Neurosurgery, Asahikawa Medical College, Asahikawa

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Tatsuya Tanaka M.D.

Tatsuya Tanaka M.D.

Department of Neurosurgery, Asahikawa Medical College, Asahikawa

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Masayuki Kunimoto M.D.

Masayuki Kunimoto M.D.

Department of Neurosurgery, Asahikawa Medical College, Asahikawa

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Yukichi Yonemasu M.D.

Yukichi Yonemasu M.D.

Department of Neurosurgery, Asahikawa Medical College, Asahikawa

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Summary

Intraperitoneal PC injections could produce secondarily generalized seizures in both the experimental models of focal epilepsy: amygdaloid kindling models and KA-in-duced limbic seizure models. In the controls, a large amount of PC induced bilateral cortical epileptiform discharges but not in the limbic structures. The epileptic foci induced by the KA injection are more sensitive to PC than the foci induced by kindling.

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