Abstract: It has been reported that apomorphine-induced stereotypy is sensitized after a chronic intermittent administration of haloperidol (HPD), but not after a chronic continuous exposure to haloperidol-decanoate (HPD-D). The present study was undertaken to investigate changes in the D₂ dopamine and muscarinic receptors in the ratstriatum after the administration of HPD intermittently and HPD-D continuously. The number of striatal [³H] spiperone binding sites increased significantly after HPD-D, but did not change after HPD. Neither the number of [³H](–)QNB binding sites nor carbachol-stimulated phosphoinositide hydrolysis changed after either HPD or HPD-D. These results indicate that the increase in striatal D₂ receptors in rats administered HPD-D represents behavioral and biochemical tolerance, and that neither the D₂ dopamine receptor supersensitivity nor muscarinic receptor hyposensitivity underlies sensitization of apomorphine-induced stereotypy.

abbreviations used are:

InsP: inositol monophosphate;
InsP₂: inositol biphosphate;
InsP₃: inositol triphosphate;
HPD: haloperidol;
HPD-D: haloperidol-decanoate;
(-)QNB: (–) quinuclidinyl benzilate;
K_D: dissociation constant;
B_max: maximal number of binding sites.

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Citing Literature

Volume41, Issue2

June 1987

Pages 311-320

Effect of Chronic Administration of Haloperidol (Intermittently) and Haloperidol-Decanoate (Continuously) on D₂ Dopamine and Muscarinic Cholinergic Receptors and on Carbachol-Stimulated Phosphoinositide Hydrolysis in the Rat Striatum

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abbreviations used are:

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Effect of Chronic Administration of Haloperidol (Intermittently) and Haloperidol-Decanoate (Continuously) on D2 Dopamine and Muscarinic Cholinergic Receptors and on Carbachol-Stimulated Phosphoinositide Hydrolysis in the Rat Striatum

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abbreviations used are:

References

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Effect of Chronic Administration of Haloperidol (Intermittently) and Haloperidol-Decanoate (Continuously) on D₂ Dopamine and Muscarinic Cholinergic Receptors and on Carbachol-Stimulated Phosphoinositide Hydrolysis in the Rat Striatum