Pubertal development and its influences on bone mineral density in Australian children and adolescents with cystic fibrosis
Helen M Buntain
Department of Respiratory Medicine, Royal Children's Hospital
Search for more papers by this authorRistan M Greer
Department of Paediatrics and Child Health, University of Queensland
Search for more papers by this authorCorresponding Author
Joseph CH Wong
Department of Nuclear Medicine and Bone Densitometry, Royal Brisbane, Hospital
Dr Helen Buntain, Department of Respiratory Medicine, Level 3 Woolworths Building, Royal Children's Hospital, Herston, QLD 4029, Australia. Fax: +61 7 3356 7328; email: [email protected]
*Present address: Department of Nuclear Medicine, Wesley Hospital, Chasely Road, Auchenflower, Qld 4066, Australia.
† Present address: Faculty of Health and Environmental Sciences, Auckland University of Technology, Private Bag 92006, Auckland 1020, New Zealand.
Search for more papers by this authorCorresponding Author
Philip J Schluter
School of Population Health, University of Queensland
Dr Helen Buntain, Department of Respiratory Medicine, Level 3 Woolworths Building, Royal Children's Hospital, Herston, QLD 4029, Australia. Fax: +61 7 3356 7328; email: [email protected]
*Present address: Department of Nuclear Medicine, Wesley Hospital, Chasely Road, Auchenflower, Qld 4066, Australia.
† Present address: Faculty of Health and Environmental Sciences, Auckland University of Technology, Private Bag 92006, Auckland 1020, New Zealand.
Search for more papers by this authorJennifer Batch
Department of Endocrinology, Royal Children's Hospital
Search for more papers by this authorPeter Lewindon
Department of Gastroenterology and Hepatology, Royal Children's Hospital
Search for more papers by this authorScott C Bell
Adult Cystic Fibrosis Unit, Department of Medicine, University of Queensland, The Prince Charles Hospital, Brisbane, Queensland, Australia
Search for more papers by this authorClaire E Wainwright
Department of Respiratory Medicine, Royal Children's Hospital
Search for more papers by this authorHelen M Buntain
Department of Respiratory Medicine, Royal Children's Hospital
Search for more papers by this authorRistan M Greer
Department of Paediatrics and Child Health, University of Queensland
Search for more papers by this authorCorresponding Author
Joseph CH Wong
Department of Nuclear Medicine and Bone Densitometry, Royal Brisbane, Hospital
Dr Helen Buntain, Department of Respiratory Medicine, Level 3 Woolworths Building, Royal Children's Hospital, Herston, QLD 4029, Australia. Fax: +61 7 3356 7328; email: [email protected]
*Present address: Department of Nuclear Medicine, Wesley Hospital, Chasely Road, Auchenflower, Qld 4066, Australia.
† Present address: Faculty of Health and Environmental Sciences, Auckland University of Technology, Private Bag 92006, Auckland 1020, New Zealand.
Search for more papers by this authorCorresponding Author
Philip J Schluter
School of Population Health, University of Queensland
Dr Helen Buntain, Department of Respiratory Medicine, Level 3 Woolworths Building, Royal Children's Hospital, Herston, QLD 4029, Australia. Fax: +61 7 3356 7328; email: [email protected]
*Present address: Department of Nuclear Medicine, Wesley Hospital, Chasely Road, Auchenflower, Qld 4066, Australia.
† Present address: Faculty of Health and Environmental Sciences, Auckland University of Technology, Private Bag 92006, Auckland 1020, New Zealand.
Search for more papers by this authorJennifer Batch
Department of Endocrinology, Royal Children's Hospital
Search for more papers by this authorPeter Lewindon
Department of Gastroenterology and Hepatology, Royal Children's Hospital
Search for more papers by this authorScott C Bell
Adult Cystic Fibrosis Unit, Department of Medicine, University of Queensland, The Prince Charles Hospital, Brisbane, Queensland, Australia
Search for more papers by this authorClaire E Wainwright
Department of Respiratory Medicine, Royal Children's Hospital
Search for more papers by this authorAbstract
Background: Pubertal delay is thought to contribute to suboptimal peak bone mass acquisition in young people with cystic fibrosis (CF), leading to an increased fracture incidence. This study aims to compare pubertal development in young people with CF with that of a local healthy population and assess the influence it has on areal bone mineral density (aBMD).
Methods: Tanner stage, age of menarche, bone age (BA), sex hormone levels and aBMD were examined in 85 individuals with CF (aged 5.3–18.1 years, 39 females) and 100 local controls (5.6–17.9 years, 54 females).
Results: Tanner stage and age of menarche were not significantly different between controls and CF. Tanner stage-adjusted mean values for follicle stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were lower in males with CF (FSH: P = 0.004, LH: P = 0.01 and T: P = 0.002). Bone age was delayed in adolescents with CF compared to controls (chronological age–BA: controls = 0.13 years (SE = 0.16), CF = 0.95 years (SE = 0.22), P = 0.003). Areal bone mineral density (adjusted for age, sex, height and lean tissue mass) was not significantly different between CF and controls. Moderate negative correlations were found between delayed BA and weight (r = −0.41, P < 0.001) and height (r = −0.41, P < 0.001).
Conclusions: There was no evidence of clinical pubertal delay or low aBMD (adjusted for short stature and lean tissue mass) in young people with CF when compared with a local population, despite lower nutritional markers, height and weight and delayed skeletal maturation.
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