Journal of Gastroenterology and Hepatology

Low prevalence of human T cell lymphotropic virus type 1 infection in patients with gastric cancer

Corresponding Author

Tetsuo Hirata

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

T Hirata, Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa, Japan. Email: [email protected]Search for more papers by this author

Manabu Nakamoto,

Manabu Nakamoto

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Masamoto Nakamura,

Masamoto Nakamura

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Nagisa Kinjo,

Nagisa Kinjo

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Akira Hokama,

Akira Hokama

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

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Fukunori Kinjo,

Fukunori Kinjo

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Jiro Fujita,

Jiro Fujita

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

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Tetsuo Hirata,

Corresponding Author

Tetsuo Hirata

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

Manabu Nakamoto,

Manabu Nakamoto

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Masamoto Nakamura,

Masamoto Nakamura

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Nagisa Kinjo,

Nagisa Kinjo

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Akira Hokama,

Akira Hokama

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

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Fukunori Kinjo,

Fukunori Kinjo

Department of Endoscopy, Ryukyu University Hospital, Okinawa, Japan

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Jiro Fujita,

Jiro Fujita

Division of Control and Prevention of Infectious Diseases, Department of Medicine and Therapeutics, Faculty of Medicine, University of the Ryukyus, and

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First published: 19 November 2007

https://doi.org/10.1111/j.1440-1746.2006.04740.x

Citations: 12

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Abstract

Background and Aim: There have been few studies on the association between human T cell lymphotropic virus type 1 (HTLV-1) infection and cancer risk. It is still controversial whether or not HTLV-1 infection affects the incidence of several cancers. With this background, we aimed to evaluate the relationship between HTLV-1 infection and the occurrence of several types of cancers.

Methods: Subjects were 699 patients with cancer aged 50 years and older diagnosed between 1991 and 2004 at the Department of Medicine and Therapeutics, Ryukyu University Hospital, Okinawa, Japan, and 1365 control patients without cancer. The association between HTLV-1 infection and cancer (biliary tract, pancreatic, esophageal, gastric, colorectal, liver, and lung cancers) was analyzed by logistic regression analysis adjusted for age and sex.

Results: The infection rate of HTLV-1 in patients with gastric cancer was significantly lower than in controls (P = 0.01, adjusted odds ratio 0.46). The infection rate of HTLV-1 was not associated with increased or decreased risk of cancers other than gastric cancer.

Conclusion: Our study indicated that the prevalence of HTLV-1 infection in patients with gastric cancer appears to be significantly lower than that in control patients.

References

1 Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC. Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc. Natl. Acad. Sci. USA 1980; 77: 7415–19.
10.1073/pnas.77.12.7415
CAS PubMed Web of Science® Google Scholar
2 Yoshida M, Miyoshi I, Hinuma Y. Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc. Natl. Acad. Sci. USA 1982; 79: 2031–5.
10.1073/pnas.79.6.2031
CAS PubMed Web of Science® Google Scholar
3 Proietti FA, Carneiro-Proietti AB, Catalan-Soares BC, Murphy EL. Global epidemiology of HTLV-I infection and associated diseases. Oncogene 2005; 24: 6058–68.
10.1038/sj.onc.1208968
CAS PubMed Web of Science® Google Scholar
4 Gessain A, Barin F, Vernant JC et al. Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis. Lancet 1985; 2: 407–10.
10.1016/S0140-6736(85)92734-5
CAS PubMed Web of Science® Google Scholar
5 Osame M, Usuku K, Izumo S et al. HTLV-I associated myelopathy, a new clinical entity. Lancet 1986; 1: 1031–2.
10.1016/S0140-6736(86)91298-5
CAS PubMed Web of Science® Google Scholar
6 Yamaguchi K, Watanabe T. Human T lymphotropic virus type-I and adult T-cell leukemia in Japan. Int. J. Hematol. 2002; 76 (Suppl. 2): 240–5.
10.1007/BF03165123
PubMed Google Scholar
7 Hirata T, Uchima N, Kishimoto K et al. Impairment of host immune response against Strongyloides stercoralis by human T cell lymphotropic virus type 1 infection. Am. J. Trop. Med. Hyg. 2006; 74: 246–9.
PubMed Web of Science® Google Scholar
8 Kozuru M, Uike N, Muta K, Goto T, Suehiro Y, Nagano M. High occurrence of primary malignant neoplasms in patients with adult T-cell leukemia/lymphoma, their siblings, and their mothers. Cancer 1996; 78: 1119–24.
10.1002/(SICI)1097-0142(19960901)78:5<1119::AID-CNCR24>3.0.CO;2-4
CAS PubMed Web of Science® Google Scholar
9 Miyazaki K, Yamaguchi K, Tohya T, Ohba T, Takatsuki K, Okamura H. Human T-cell leukemia virus type I infection as an oncogenic and prognostic risk factor in cervical and vaginal carcinoma. Obstet. Gynecol. 1991; 77: 107–10.
CAS PubMed Web of Science® Google Scholar
10 Matsuzaki H, Asou N, Kawaguchi Y et al. Human T-cell leukemia virus type 1 associated with small cell lung cancer. Cancer 1990; 66: 1763–8.
10.1002/1097-0142(19901015)66:8<1763::AID-CNCR2820660821>3.0.CO;2-A
PubMed Google Scholar
11 Asou N, Kumagai T, Uekihara S et al. HTLV-I seroprevalence in patients with malignancy. Cancer 1986; 58: 903–7.
10.1002/1097-0142(19860815)58:4<903::AID-CNCR2820580417>3.0.CO;2-J
CAS PubMed Web of Science® Google Scholar
12 Arisawa K, Sobue T, Yoshimi I et al. Human T-lymphotropic virus type-I infection, survival and cancer risk in southwestern Japan: a prospective cohort study. Cancer Causes Control 2003; 14: 889–96.
10.1023/B:CACO.0000003853.82298.96
PubMed Web of Science® Google Scholar
13 Arisawa K, Soda M, Akahoshi M et al. Human T-lymphotropic virus type-I infection, antibody titers and cause-specific mortality among atomic-bomb survivors. Jpn. J. Cancer Res. 1998; 89: 797–805.
10.1111/j.1349-7006.1998.tb00631.x
CAS PubMed Web of Science® Google Scholar
14 Fujino R, Kawato K, Ikeda M, Miyakoshi H, Mizukoshi M, Imai J. Improvement of gelatin particle agglutination test for detection of anti-HTLV-I antibody. Jpn. J. Cancer Res. 1991; 82: 367–70.
10.1111/j.1349-7006.1991.tb01856.x
CAS PubMed Web of Science® Google Scholar
15 Uemura N, Okamoto S, Yamamoto S et al. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 2001; 345: 784–9.
10.1056/NEJMoa001999
CAS PubMed Web of Science® Google Scholar
16 Bamford KB, Fan X, Crowe SE et al. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology 1998; 114: 482–92.
10.1016/S0016-5085(98)70531-1
CAS PubMed Web of Science® Google Scholar
17 Deml L, Aigner M, Decker J et al. Characterization of the Helicobacter pylori cysteine-rich protein A as a T-helper cell type 1 polarizing agent. Infect. Immun. 2005; 73: 4732–42.
10.1128/IAI.73.8.4732-4742.2005
CAS PubMed Web of Science® Google Scholar
18 Isomoto H, Mizuta Y, Fukushima K et al. Low prevalence of Helicobacter pylori in individuals with HTLV-I infection. Eur. J. Gastroenterol. Hepatol. 1999; 11: 497–502.
10.1097/00042737-199905000-00006
CAS PubMed Web of Science® Google Scholar
19 Welles SL, Tachibana N, Okayama A et al. Decreased reactivity to PPD among HTLV-I carriers in relation to virus and hematologic status. Int. J. Cancer 1994; 56: 337–40.
10.1002/ijc.2910560307
CAS PubMed Web of Science® Google Scholar
20 Katsuki T, Katsuki K, Imai J, Hinuma Y. Immune suppression in healthy carriers of adult T-cell leukemia retrovirus (HTLV-I): impairment of T-cell control of Epstein-Barr virus-infected B-cells. Jpn. J. Cancer Res. 1987; 78: 639–42.
PubMed Web of Science® Google Scholar
21 Boschi-Pinto C, Stuver S, Okayama A et al. A follow-up study of morbidity and mortality associated with hepatitis C virus infection and its interaction with human T lymphotropic virus type I in Miyazaki, Japan. J. Infect. Dis. 2000; 181: 35–41.
10.1086/315177
CAS PubMed Web of Science® Google Scholar
22 Nagai M, Brennan MB, Sakai JA, Mora CA, Jacobson S. CD8 (+) T cells are an in vivo reservoir for human T-cell lymphotropic virus type I. Blood 2001; 98: 1858–61.
10.1182/blood.V98.6.1858
CAS PubMed Web of Science® Google Scholar
23 Yasunaga Ji Sakai T, Nosaka K et al. Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: its implications in the immunodeficient state. Blood 2001; 97: 3177–83.
10.1182/blood.V97.10.3177
PubMed Web of Science® Google Scholar
24 Hansen S, Melby KK, Aase S et al. Helicobacter pylori infection and risk of cardia cancer and non-cardia gastric cancer. A nested case-control study. Scand. J. Gastroenterol. 1999; 34: 353–60.
10.1080/003655299750026353
CAS PubMed Web of Science® Google Scholar
25 Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001; 49: 347–53.
10.1136/gut.49.3.347
PubMed Web of Science® Google Scholar

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Volume22, Issue12

December 2007

Pages 2238-2241

Low prevalence of human T cell lymphotropic virus type 1 infection in patients with gastric cancer

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Low prevalence of human T cell lymphotropic virus type 1 infection in patients with gastric cancer

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