Psychosocial and behavioural factors in heart transplant candidates – an overview
Heike Spaderna
Psychological Institute, Johannes Gutenberg-University, Mainz, Germany
Search for more papers by this authorJacqueline M. A. Smits
Eurotransplant International Foundation, Leiden, The Netherlands
Search for more papers by this authorAxel O. Rahmel
Eurotransplant International Foundation, Leiden, The Netherlands
Search for more papers by this authorGerdi Weidner
Preventive Medicine Research Institute, Sausalito, CA, USA
Search for more papers by this authorHeike Spaderna
Psychological Institute, Johannes Gutenberg-University, Mainz, Germany
Search for more papers by this authorJacqueline M. A. Smits
Eurotransplant International Foundation, Leiden, The Netherlands
Search for more papers by this authorAxel O. Rahmel
Eurotransplant International Foundation, Leiden, The Netherlands
Search for more papers by this authorGerdi Weidner
Preventive Medicine Research Institute, Sausalito, CA, USA
Search for more papers by this authorSummary
Mortality among heart transplant (HTX) candidates remains high. This review of the literature shows that psychosocial characteristics like depression, social isolation and coping strategies contribute to morbidity and mortality in heart failure (HF) patients, and may also be relevant to the prognosis of HTX candidates. Based on the research to date, physical activity favourably affects subjective and objective parameters not only in HF patients, but also in HTX candidates. Depression is prevalent among HTX candidates, especially in ischaemic patients, and seems to be related to earlier transplantation. Findings on the effects of depression on pretransplant mortality are conflicting. Not much is known concerning social isolation, coping, nutrition, or weight loss in this patient group. Identification of modifiable psychosocial and behavioural variables related to clinical status in this patient group is clearly needed and will aid the development of behavioural interventions to supplement medical therapies.
References
- 1 Boyle A, Colvin-Adams M. Recipient selection and management. Semin Thorac Cardiovasc Surg 2004; 16: 358.
- 2 Gardner RS, McDonagh TA, MacDonald M, Dargie HJ, Murday AJ, Petrie MC. Who needs a heart transplant? Eur Heart J 2006; 27: 770.
- 3 Deng MC. Cardiac transplantation. Heart 2002; 87: 177.
- 4 Mehra MR, Kobashigawa J, Starling R, et al. Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates–2006. J Heart Lung Transplant 2006; 25: 1024.
- 5 Ständige Kommission Organtransplantation der Bundesärztekammer. Richtlinien zur Organtransplantation gemäß§16 TPG. [online]; Available at: http://www.baek.de/RiliOrgantrans20070323-1.pdf [accessed on November 24, 2003].
- 6 Olivari M-T. Cardiac transplantation: Current indications, short- and long-term results, economic implications, and future developments. J Card Fail 1996; 2: 141.
- 7 Cohen B, Persijn G. Eurotransplant Annual Report 2004. Leiden: Eurotransplant International Foundation, 2005: p. 52.
- 8 Grady KL, Jalowiec A, White-Williams C, et al. Predictors of quality of life in patients with advanced heart failure awaiting transplantation. J Heart Lung Transplant 1995; 14: 2.
- 9 Hecker JE, Norvell N, Hills H. Psychologic assessment of candidates for heart transplantation: Toward a normative data base. J Heart Transplant 1989; 8: 171.
- 10 Jalowiec A, Grady K, White-Williams C. Stressors in patients awaiting a heart transplant. Behav Med 1994; 19: 145.
- 11 Muirhead J, Meyerowitz BE, Leedham B, Eastburn TE, Merrill WH, Frist WH. Quality of life and coping in patients awaiting heart transplantation. J Heart Lung Transplant 1992; 11: 265.
- 12 Cupples SA, Nolan MT, Augustine SM, Kynoch D. Perceived stressors and coping strategies among heart transplant candidates. J Transpl Coord 1998; 8: 179.
- 13 Jaeger EM, Gromzik H. Belastungen, Coping und emotionale Belastungsreaktionen bei Patienten in der Wartezeit vor einer Herztransplantation. Tx Med 2000; Suppl.: 118.
- 14 Trunzo JJ, Petrucci RJ, Carter A, Donofrio N. Use of the MMPI and MMPI-2 in patients being evaluated for cardiac transplant. Psychol Rep 1999; 85: 1105.
- 15 Zipfel S, Löwe B, Paschke T, et al. Emotionales Befinden von Patienten auf der Warteliste für eine Herztransplantation. Z Kardiol 1998; 87: 436.
- 16 Cupples S, Dew MA, Grady KL, et al. Report of the Psychosocial Outcomes Workgroup of the Nursing and Social Sciences Council of the International Society for Heart and Lung Transplantation: present status of research on psychosocial outcomes in cardiothoracic transplantation: review and recommendations for the field. J Heart Lung Transplant 2006; 25: 716.
- 17 Dew MA, Roth LH, Schulberg HC, et al. Prevalence and predictors of depression and anxiety-related disorders during the year after heart transplantation. Gen Hosp Psychiatry 1996; 18: 48S.
- 18 Dew MA, Kormos RL, Roth LH, Murali S, DiMartini A, Griffith BP. Early post-transplant medical compliance and mental health predict physical morbidity and mortality one to three years after heart transplantation. J Heart Lung Transplant 1999; 18: 549.
- 19 Grady KL, Jalowiec A, White-Williams C. Improvements in quality of life in patients with heart failure who undergo transplantation. J Heart Lung Transplant 1996; 15: 749.
- 20 Grady KL, Jalowiec A, White-Williams C. Patient compliance at one year and two years after heart transplantation. J Heart Lung Transplant 1998; 17: 383.
- 21 Grady KL, Jalowiec A, White-Williams C. Preoperative psychosocial predictors of hospital length of stay after heart transplantation. J Cardiovasc Nurs 1999; 14: 12.
- 22 Leedham B, Meyerowitz BE, Muirhead J, Frist WH. Positive expectations predict health after heart transplantation. Health Psychol 1995; 14: 74.
- 23 Paris W, Muchmore J, Pribil A, Zuhdi N, Cooper DKC. Study of the relative incidence of psychosocial factors before and after heart transplantation and the influence of posttransplantation psychosocial factors of heart transplantation outcome. J Heart Lung Transplant 1994; 13: 424.
- 24 Zipfel S, Schneider A, Wild B, et al. Effect of depressive symptoms on survival after heart transplantation. Psychosom Med 2002; 64: 740.
- 25 Dew MA, Switzer GE, DiMartini AF, Matukaitis J, Fitzgerald MG, Kormos RL. Psychosocial assessments and outcomes in organ transplantation. Prog Transplant 2000; 10: 239.
- 26 Iestra JA, Kromhout MPH, Van Der Schouw YT, Grobbee DE, Boshuizen HC, Van Staveren WA. Effect size estimates of lifestyle and dietary changes on all-cause mortality in coronary artery disease patients. A systematic review. Circulation 2005; 112: 924.
- 27 Rees K, Taylor RS, Singh S, Coats AJS, Ebrahim S. Exercise based rehabilitation for heart failure. Cochrane Database Syst Rev 2004; Issue 3. Art. No.: CD003331. pub2. DOI: 10.1002/14651858. CD003331.pub2. Available at http://www.mrw.interscience.wiley.com/cochrane/ clsysrev/articles/CD003331/frame.html
- 28 Rozanski A, Kubzansky L. Psychologic functioning and physical health: a paradigm of flexibility. Psychosom Med 2005; 67(Suppl. 1): S47.
- 29
Spaderna H,
Weidner G.
Psychosoziale Aspekte und Gesundheitsverhalten bei Herzinsuffizienz - Ein Überblick.
Z Gesundheitspsychol
2006; 14: 145.
10.1026/0943-8149.14.4.145 Google Scholar
- 30 Aaronson KD, Schwartz JS, Chen T-M, Wong K-L, Goin JE, Mancini DM. Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation. Circulation 1997; 95: 2660.
- 31 Lee DS, Austin PC, Rouleau JL, Liu PP, Naimark D, Tu JV. Predicting mortality among patients hospitalized for heart failure. J Am Med Assoc 2003; 290: 2581.
- 32 Levy WC, Mozaffarian D, Linker DT, et al. The Seattle Heart Failure Model: prediction of survival in heart failure. Circulation 2006; 113: 1424.
- 33 Lund LH, Aaronson KD, Mancini DM. Predicting survival in ambulatory patients with severe heart failure on beta-blocker therapy. Am J Cardiol 2003; 92: 1350.
- 34 Smits JMA, Deng MC, Hummel M, et al. A prognostic model for predicting waiting-list mortality for a total national cohort of adult heart-transplant candidates. Transplantation 2003; 76: 1185.
- 35 Smits JMA, Vanhaecke J, Haverich A, et al. Waiting for a thoracic transplant in Eurotransplant. Transpl Int 2006; 19: 54.
- 36 Frantz RP, Olson LJ. Recipient selection and management before cardiac transplantation. Am J Med Sci 1997; 314: 139.
- 37
Pini D,
Ardino L,
Genovese L, et al.
Predictors of survival in heart failure patients in NYHA class IV (Abstract).
J Heart Lung Transplant
2004; 23(Suppl.): S58.
10.1016/j.healun.2003.11.048 Google Scholar
- 38 Riedmayr MI, Tammen AR, Behr TM, et al. Perspektiven von Patienten mit terminaler Herzinsuffizienz: Lebensqualität und psychisches Befinden vor und im ersten Jahr nach Herztransplantation. Z Kardiol 1998; 87: 808.
- 39 Deng MC, De Meester JMJ, Smits JMA, Heinecke J, Scheld HH. Effect of receiving a heart transplant: analysis of a national cohort entered on to a waiting list, stratified by heart failure severity. BMJ 2000; 321: 540.
- 40 Shah NR, Rogers JG, Ewald GA, et al. Survival of patients removed from the heart transplant waiting list. J Thorac Cardiovasc Surg 2004; 127: 1481.
- 41 World Health Organization. International Statistical Classification of Diseases and Related Health Problems, Tenth revision - ICD-10, 2nd edn. Geneva: World Health Organisation, 2005.
- 42 Faris R, Purcell H, Henein MY, Coats AJ. Clinical depression is common and significantly associated with reduced survival in patients with non-ischaemic heart failure. Eur J Heart Fail 2002; 4: 541.
- 43 Freedland KE, Rich MW, Skala JA, Carney RM, Davila-Roman VG, Jaffe AS. Prevalence of depression in hospitalized patients with congestive heart failure. Psychosom Med 2003; 65: 119.
- 44 Jiang W, Alexander J, Christopher E, et al. Relationship of depression to increased risk of mortality and rehospitalization in patients with congestive heart failure. Arch Intern Med 2001; 161: 1849.
- 45 Sullivan MD, Levy WC, Crane BA, Russo JE, Spertus JA. Usefulness of depression to predict time to combined end point of transplant or death for outpatients with advanced heart failure. Am J Cardiol 2004; 94: 1577.
- 46 Friedman MM, Griffin JA. Relationship of physical symptoms and physical functioning to depression in patients with heart failure. Heart Lung 2001; 30: 98.
- 47 Jiang W, Blumenthal JA. Depression and ischemic heart disease: overview of the evidence and treatment implications. Curr Psychiatry Rep 2003; 5: 47.
- 48 Vaccarino V, Kasl SV, Abramson J, Krumholz HM. Depressive symptoms and risk of functional decline and death in patients with heart failure. J Am Coll Cardiol 2001; 38: 199.
- 49 Zellweger MJ, Osterwalder RH, Langewitz W, Pfisterer ME. Coronary artery disease and depression. Eur Heart J 2004; 25: 3.
- 50 Zipfel S, Löwe B, Paschke T, et al. Psychological distress in patients awaiting heart transplantation. J Psychosom Res 1998; 45: 465.
- 51 Zipfel S, Löwe B, Schneider A, Herzog W, Bergmann G. Lebensqualität, Depressivität und Krankheitsverarbeitung bei Patienten in der Wartezeit auf eine Herztransplantation. Psychother Psychosom Med Psychol 1999; 49: 187.
- 52 Herrmann C, Buss U, Snaith RP. Hospital Anxiety and Depression Scale - Deutsche Version: Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin. Bern: Verlag Hans Huber, 1995.
- 53 Herrmann-Lingen C, Buss U, Snaith RP. HADS-D Hospital Anxiety and Depression Scale - Deutsche Version. Ein Fragebogen zur Erfassung von Angst und Depressivität in der somatischen Medizin. 2. Aufl. Bern: Huber, 2005.
- 54 Spaderna H, Weidner G, Krohne HW. Waiting for a new heart: early experience from a multi-site study of medical and psychological predictors of pre-transplant outcomes (Abstract). Psychol Health 2005; 20(Suppl. 1): 255.
- 55 Spaderna H, Zahn D, Krohne HW, Weidner G. Warten auf ein neues Herz: Erste Baseline-Ergebnisse einer prospektiven multizentrischen Studie zu medizinischen und psychosozialen Prädiktoren der Outcomes während der Wartezeit auf eine Herztransplantation. Tx Med 2006; 18(Suppl.): 183.
- 56 Zahn D, Spaderna H, Smits JM, Krohne HW, Weidner G. Warten auf ein neues Herz: Erste Zusammenhänge zwischen der Ätiologie der Herzinsuffizienz und dem Ausmaß psychosozialer Belastung bei Kandidaten für eine Herztransplantation (HTX). In: Y Stöbel-Richter, A Hinz, C Schröder et al., eds. Gemeinsamer Kongress der Deutschen Gesellschaft für Medizinische Psychologie und der Deutschen Gesellschaft für Medizinische Soziologie. Science Publishers, Pabst, 2006: 307.
- 57 Koenig HG. Depression in hospitalized older patients with congestive heart failure. Gen Hosp Psychiatry 1998; 20: 29.
- 58 Murberg TA, Bru E, Svebak S, Tveteras R, Aarsland T. Depressed mood and subjective health symptoms as predictors of mortality in patients with congestive heart failure: a two-years follow-up study. Int J Psychiatry Med 1999; 29: 311.
- 59 Skotzko CE, Krichten C, Zietowski G, et al. Depression is common and precludes accurate assessment of functional status in elderly patients with congestive heart failure. J Card Fail 2000; 6: 300.
- 60 Yu DSF, Lee TF, Woo J, Thompson DR. Correlates of psychological distress in elderly patients with congestive heart failure. J Psychosom Res 2004; 57: 573.
- 61 Clarke SP, Frasure-Smith N, Lespérance F, Bourassa MG. Psychosocial factors as predictors of functional status at 1 year in patients with left ventricular dysfunction. Res Nurs Health 2000; 23: 290.
- 62 Jünger J, Schellberg D, Müller-Tasch T, et al. Depression increasingly predicts mortality in the course of congestive heart failure. Eur J Heart Fail 2005; 7: 261.
- 63 Westlake C, Dracup K, Fonarow G, Hamilton M. Depression in patients with heart failure. J Card Fail 2005; 11: 30.
- 64 Martensson J, Dracup K, Canary C, Fridlund B. Living with heart failure: depression and quality of life in patients and spouses. J Heart Lung Transplant 2003; 22: 460.
- 65 Sullivan MD, Levy WC, Russo JE, Spertus JA. Depression and health status in patients with advanced heart failure: a prospective study in tertiary care. J Card Fail 2004; 10: 390.
- 66 Gottlieb SS, Khatta M, Friedmann E, et al. The influence of age, gender, and race on the prevalence of depression in heart failure patients. J Am Coll Cardiol 2004; 43: 1542.
- 67 Jiang W, Kuchibhatla M, Cuffe MS, et al. Prognostic value of anxiety and depression in patients with chronic heart failure. Circulation 2004; 110: 3452.
- 68 Brandwin M, Trask PC, Schwartz SM, Clifford M. Personality predictors of mortality in cardiac transplant candidates and recipients. J Psychosom Res 2000; 49: 141.
- 69 DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment. Arch Intern Med 2000; 160: 2101.
- 70 Ziegelstein RC, Fauerbach JA, Stevens SS, Romanelli J, Richter DP, Bush DE. Patients with depression are less likely to follow recommendations to reduce cardiac risk during recovery from a myocardial infarction. Arch Intern Med 2000; 160: 1818.
- 71 Van Der Wal MHL, Jaarsma T, Moser DK, Veeger NJGM, Van Gilst WH, Van Veldhuisen DJ. Compliance in heart failure patients: the importance of knowledge and beliefs. Eur Heart J 2006; 27: 434.
- 72 Bunzel B, Laederach-Hofmann K. Solid organ transplantation: are there predictors for posttransplant noncompliance? A literature overview. Transplantation 2000; 70: 711.
- 73 De Geest S, Dobbels F, Martin S, Willems K, Vanhaecke J. Clinical risk associated with appointment noncompliance in heart transplant recipients. Prog Transplant 2000; 10: 162.
- 74 Dobbels F, Vanhaecke J, Desmyttere A, Dupont L, Nevens F, De Geest S. Prevalence and correlates of self-reported pretransplant nonadherence with medication in heart, liver, and lung transplant candidates. Transplantation 2005; 79: 1588.
- 75 Sullivan MD, Simon G, Spertus J, Russo J. Depression-related costs in heart failure care. Arch Intern Med 2002; 162: 1860.
- 76 Herrmann-Lingen C, Binder L, Klinge M, et al. High plasma levels of N-terminal pro-atrial natriuretic peptide associated with low anxiety in severe heart failure. Psychosom Med 2003; 65: 517.
- 77 Majani G, Pierobon A, Giardini A, et al. Relationship between psychological profile and cardiological variables in chronic heart failure. The role of patient subjectivity. Eur Heart J 1999; 20: 1579.
- 78 Hinz A, Schwarz R. Angst und Depression in der Allgemeinbevölkerung. Eine Normierungsstudie zur Hospital Anxiety and Depression Scale. PPmP 2001; 51: 193.
- 79 Krohne HW. Vigilance and cognitive avoidance as concepts in coping research. In: HW Krohne, ed. Attention and Avoidance: Strategies in Coping with Aversiveness. Toronto, Göttingen: Hogrefe & Huber, 1993: 19.
- 80
Krohne HW.
Stress and coping theories. In: NJ Smelser,
PB Baltes, eds. The International Encyclopedia of the Social and Behavioral Sciences. Oxford, UK: Elsevier, 2001: 15163.
10.1016/B0-08-043076-7/03817-1 Google Scholar
- 81 Doering LV, Dracup K, Caldwell M, et al. Is coping style linked to emotional states in heart failure patients? J Card Fail 2004; 10: 344.
- 82 Burker EJ, Evon DM, Losielle MM, Finkel JB, Mill MR. Coping predicts depression and disability in heart transplant candidates. J Psychosom Res 2005; 59: 215.
- 83 Myaskovsky L, Dew MA, Switzer GE, Hall M, Kormos RL, Goycoolea JM. Avoidant coping with health problems is related to poorer quality of life among lung transplant candidates. Prog Transplant 2003; 13: 183.
- 84 Murberg TA, Furze G, Bru E. Avoidance coping styles predict mortality among patients with congestive heart failure: a 6-year follow-up study. Pers Individ Dif 2004; 36: 757.
- 85 Young LD, Schweiger J, Beitzinger J, McManus R, Bloedel C, Koob J. Denial in heart transplant candidates. Psychother Psychosom 1991; 55: 141.
- 86 Schwarzer R, Rieckmann N. Social support, cardiovascular disease, and mortality. In: G Weidner, MS Kopp, M Kristenson, eds. Heart Disease: Environment, Stress and Gender. Amsterdam: IOS Press, 2002: 185.
- 87 Cacioppo JT, Hawley LC. Social isolation and health, with an emphasis on underlying mechanisms. Perspect Biol Med 2003; 46(Suppl.): S39.
- 88 Hemingway H, Marmot M. Psychosocial factors in the aetiology and prognosis of coronary heart disease: systematic review of prospective cohort studies. BMJ 1999; 318: 1460.
- 89 Luttik ML, Jaarsma T, Moser D, Sanderman R, Van Veldhuisen DJ. The importance and impact of social support on outcomes in patients with heart failure. An overview of the literature. J Cardiovasc Nurs 2005; 20: 162.
- 90 Metayer C, Coughlin SS, McCarthy EP. Marital status as a predictor of survival in idiopathic dilated cardiomyopathy: the Washington, DC dilated cardiomyopathy study. Eur J Epidemiol 1996; 12: 573.
- 91 Murberg TA, Bru E. Social relationships and mortality in patients with congestive heart failure. J Psychosom Res 2001; 51: 521.
- 92 Krumholz HM, Butler J, Miller JI, et al. Prognostic importance of emotional support for elderly patients hospitalized with heart failure. Circulation 1998; 97: 958.
- 93 Holahan CJ, Moos RH, Holahan CK, Brennan PL. Social support, coping, and depressive symptoms in a late-middle-aged sample of patients reporting cardiac illness. Health Psychol 1995; 14: 152.
- 94 Murberg TA, Bru E, Aarsland T, Svebak S. Social support, social disability and their role as predictors of depression among patients with congestive heart failure. Scand J Soc Med 1998; 26: 87.
- 95 Havranek EP, Spertus JA, Masoudi FA, Jones PG, Rumsfeld JS. Predictors of the onset of depressive symptoms in patients with heart failure. J Am Coll Cardiol 2004; 44: 2333.
- 96 Cupples SA, Spruill LC. Evaluation criteria for the pretransplant patient. Crit Care Nurs Clin North Am 2000; 12: 35.
- 97 Favaloro RR, Perrone SV, Moscoloni SE, et al. Value of pre-heart-transplant psychological evaluation: long-term follow-up. Transplant Proc 1999; 31: 3000.
- 98 Scheld HH, Deng MC, Hammel D, Schmid C. Leitfaden Herztransplantation. Interdisziplinäre Betreuung vor, während und nach Herztransplantation. Darmstadt: Steinkopff, 2001: 355.
- 99 Burker EJ, Evon DM, Ascari JC, Loiselle MM, Finkel JB, Mill MR. Relationship between coping and depression in heart transplant candidates and their spouses. Prog Transplant 2006; 16: 215.
- 100 Swedberg K, Cleland J, Dargie H, et al. Guidelines for the diagnosis and treatment of Chronic Heart Failure: executive summary (update 2005). Eur Heart J 2005; 26: 1115.
- 101 Jessup M, Banner N, Brozena S, et al. Optimal pharmacologic and non-pharmacologic management of cardiac transplant candidates: approaches to be considered prior to transplant evaluation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates–2006. J Heart Lung Transplant 2006; 25: 1003.
- 102 Remme WJ, McMurray JJV, Rauch B, et al. Public awareness of heart failure in Europe: first results from SHAPE. Eur Heart J 2005; 26: 2413.
- 103 Evangelista LS, Miller PS. Overweight and obesity in the context of heart failure: implications for practice and future research. J Cardiovasc Nurs 2006; 21: 27.
- 104 Evangelista LS, Moser DK, Westlake C, Hamilton MA, Fonarow GC, Dracup K. Impact of obesity on quality of life and depression in patients with heart failure. Eur J Heart Fail 2006; 8: 750.
- 105 Piña IL, Apstein CS, Balady GJ, et al. Exercise and heart failure: a statement from the American Heart Association Committee on exercise, rehabilitation, and prevention. Circulation 2003; 107: 1210.
- 106 Willenheimer R, Erhardt L, Cline C, Rydberg E, Israelsson B. Exercise training in heart failure improves quality of life and exercise capacity. Eur Heart J 1998; 19: 774.
- 107 Levinger I, Bronks R, Cody DV, Linton I, Davie A. Resistance training for chronic heart failure patients on beta blocker medications. Int J Cardiol 2005; 102: 493.
- 108 Senden PJ, Sabelis LW, Zonderland ML, Hulzebos EH, Bol E, Mosterd WL. The effect of physical training on workload, upper leg muscle function and muscle areas in patients with chronic heart failure. Int J Cardiol 2005; 100: 293.
- 109 Passino C, Severino S, Poletti R, et al. Aerobic training decreases B-type natriuretic peptide expression and adrenergic activation in patients with heart failure. J Am Coll Cardiol 2006; 47: 1835.
- 110 Quittan M, Sturm B, Wiesinger GF, Pacher R, Fialka-Moser V. Quality of life in patients with chronic heart failure: a randomized controlled trial of changes induced by a regular exercise program. Scand J Rehabil Med 1999; 31: 223.
- 111 Erbs S, Linke A, Gielen S, et al. Exercise training in patients with severe chronic heart failure: impact on left ventricular performance and cardiac size. A retrospective analysis of the Leipzig Heart Failure Training Trial. J Cardiovasc Risk 2003; 10: 336.
- 112 Hambrecht R, Schuler G. Die körperliche Belastbarkeit des herzinsuffizienten Patienten. Training bei Herzinsuffizienz? Internist 2000; 41: 269.
- 113 The ExTraMATCH Collaborative. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 2004; 328: 189.
- 114 Smart N, Marwick TH. Exercise training for patients with heart failure: a systematic review of factors that improve mortality and morbidity. Am J Med 2004; 116: 693.
- 115 Tyni-Lenné R, Gordon A, Jensen-Urstad M, Dencker K, Jansson E, Sylven C. Aerobic training involving a minor muscle mass shows greater efficiency than training a major muscle mass in chronic heart failure patients. J Card Fail 1999; 5: 300.
- 116 Belardinelli R, Georgiou D, Scocco V, Barstow TJ, Purcaro A. Low intensity exercise training in patients with chronic heart failure. J Am Coll Cardiol 1995; 26: 975.
- 117 Stevenson LW, Steimle AE, Fonarow G, et al. Improvement in exercise capacity of candidates awaiting heart transplantation. J Am Coll Cardiol 1995; 25: 163.
- 118 Spaderna H, Becker A, Zahn D, Smits JMA, Krohne HW, Weidner G. Warten auf ein neues Herz: Erste Ergebnisse zur körperlichen Aktivität von Patienten auf der Warteliste für eine Herztransplantation (HTX). In: Y Stöbel-Richter, A Hinz, C Schröder et al., eds. Gemeinsamer Kongress-Deutsche Gesellschaft für Medizinische Psychologie und Deutsche Gesellschaft für Medizinische Soziologie. Lengerich, Pabst Science Publishers, 2006: 265.
- 119 Smith SC Jr, Allen J, Blair SN, et al. AHA/ACC guidelines for secondary prevention for patients with coronary and other atherosclerotic vascular disease: 2006 update: endorsed by the National Heart, Lung, and Blood Institute. Circulation 2006; 113: 2363.
- 120 Hooper L, Griffiths E, Abrahams B, et al. Dietetic guidelines: diet in secondary prevention of cardiovascular diseases (first update, June 2003). J Hum Nutr Diet 2004; 17: 337.
- 121 Mehra MR, Lavie CJ, Ventura HO, Milani RV. Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure. J Heart Lung Transplant 2006; 25: 834.
- 122 Witte KK, Nikitin NP, Parker AC, et al. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005; 26: 2238.
- 123 Hunt SA, Abraham WT, Chin MH, et al. ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society. Circulation 2005; 112: e154.
- 124 Grady KL, White-Williams C, Naftel D, et al. Are preoperative obesity and cachexia risk factors for post heart transplant morbidity and mortality: a multi-institutional study of preoperative weight-height indices. J Heart Lung Transplant 1999; 18: 750.
- 125 Curtis JP, Selter JG, Wang Y, et al. The obesity paradox: body mass index and outcomes in patients with heart failure. Arch Intern Med 2005; 165: 55.
- 126 Kalantar-Zadeh K, Block G, Horwich T, Fonarow GC. Reverse epidemiology of conventional cardiovascular risk factors in patients with chronic heart failure. J Am Coll Cardiol 2004; 43: 1439.
- 127 Rauchhaus M, Clark AL, Doehner W, et al. The relationship between cholesterol and survival in patients with chronic heart failure. J Am Coll Cardiol 2003; 42: 1933.
- 128 Pasini E, Opasich C, Pastoris O, Aquilani R. Inadequate nutritional intake for daily life activity of clinical stable patients with chronic heart failure. Am J Cardiol 2004; 93(Suppl.): 41A.
- 129 Toth MJ. Comparing energy expenditure data among individuals differing in body size and composition: statistical and physiological considerations. Curr Opin Clin Nutr Metab Care 2001; 4: 391.
- 130 Obisesan TO, Toth MJ, Donaldson K, et al. Energy expenditure and symptom severity in men with heart failure. Am J Cardiol 1996; 77: 1250.
- 131 Aquilani R, Opasich C, Verri M, et al. Is nutritional intake adequate in chronic heart failure patients? J Am Coll Cardiol 2003; 42: 1218.
- 132 Jacobsson A, Pihl E, Martensson J, Fridlund B. Emotions, the meaning of food and heart failure: a grounded theory study. J Adv Nurs 2004; 46: 514.
- 133 Bentley B, De Jong MJ, Moser DK, Peden AR. Factors related to nonadherence to low sodium diet recommendations in heart failure patients. Eur J Cardiovasc Nurs 2005; 4: 331.
- 134 Page S, Rudkowska I, Giannetti N, Plourde H. Nutrition therapy improves outcomes in ambulatory heart failure clinic [Abstract]. J Card Fail 2005; 11(Suppl.): S198.
- 135 Deng MC, Smits JMA, De Meester J, Hummel M, Schoendube F, Scheld HH. Heart transplantation is indicated only in the most severely ill patient: perspectives from the German heart transplant experience. Curr Opin Cardiol 2001; 16: 97.
- 136 Deng MC, Smits JMA, Packer M. Selecting patients for heart transplantation: which patients are too well for transplant? Curr Opin Cardiol 2002; 17: 137.
- 137 Deng MC, Smits JMA, Young JB. Proposition: the benefit of cardiac transplantation in stable outpatients with heart failure should be tested in a randomized trial. J Heart Lung Transplant 2003; 22: 113.
- 138 Jimenez J, Bennett Edwards L, Higgins R, Bauerlein J, Pham S, Mallon S. Should stable UNOS Status 2 patients be transplanted? J Heart Lung Transplant 2005; 24: 178.
- 139 Freudenberger RS, Kim JW, Tawfik I, Sonnenberg FA. Optimal medical therapy is superior to transplantation for the treatment of class I, II, and III heart failure. A decision analytic approach. Circulation 2006; 114(Suppl. I): I.
- 140 Krakauer H, Lin MJ, Bailey RC. Projected survival benefit as criterion for listing and organ allocation in heart transplantation. J Heart Lung Transplant 2005; 24: 680.
- 141 Coats AJ. Advances in the non-drug, non-surgical, non-device management of chronic heart failure. Int J Cardiol 2005; 100: 1.
- 142 Colonna P, Sorino M, D'Agostino C, et al. Nonpharmacologic care of heart failure: Counseling, dietary restriction, rehabilitation, treatment of sleep apnea, and ultrafiltration. Am J Cardiol 2003; 91(Suppl.): 41F.
- 143 Leon AS, Franklin BA, Costa F, et al. Cardiac rehabilitation and secondary prevention of coronary heart disease. An American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity), in collaboration with the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation 2005; 111: 369.