Volume 3, Issue 6 pp. 442-448
Full Access

Observations on the Direct Coombs Test on Cord Erythrocytes after the Addition of Complement

William Pollack

Corresponding Author

William Pollack

Division of Serological Development, Ortho Research Foundation, Raritan, New Jersey

Division of Serological Development, Ortho Research Foundation, Raritan, N. J. (USA)Search for more papers by this author
Alice M. Reiss

Alice M. Reiss

Division of Serological Development, Ortho Research Foundation, Raritan, New Jersey

Search for more papers by this author
Margaret Treacy

Margaret Treacy

Division of Serological Development, Ortho Research Foundation, Raritan, New Jersey

Search for more papers by this author
First published: November 1958
Citations: 3

Abstract

Summary

  • 1

    A positive direct antiglobulin test was obtained on the cord cells of babies with clinical signs of hemolytic disease after exposure of the cells to fresh compatible adult serum.

  • 2

    Adult serum heated at 56° C. for 30 minutes did not exhibit this effect.

  • 3

    Family studies failed to provide evidence of atypical antibodies in the majority of cases.

Résumé

  • Avec le sang de nouveau-nés présentant les symptômes cliniques de la maladie hémolytique, le test antiglobuline direct se montra positif après incubation des hématies avec du sérum frais compatible d'adulte.

  • Cet effet fut aboli par chauffage du sérum d'adulte à 56° pendant 30 minutes.

  • 3 Dans la plupart de ces cas, l'étude sérologique de la famille n'a pas pu mettre en évidence d'anticorps irréguliers.

Zusammenfassung

Nabelschnurblutproben von Kindern mit den klinischen Zeichen eines Morbus haemolyticus neonatorum zeigten nach Zugabe von frischem kompatiblem Erwachsenenserum einen positiven direkten Coombstest. Nach Zugabe von Serum, welches bei 56° C während 30 Minuten inaktiviert worden war, blieb der direkte Coombstest negativ. In der Mehrzahl der Fälle konnten in den mütterlichen Seren keine atypischen Antikörper nachgewiesen werden.

The full text of this article hosted at iucr.org is unavailable due to technical difficulties.