Associations of overweight with insulin resistance, β-cell function and inflammatory markers in Chinese adolescents
Alice PS Kong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorKai-Chow Choi
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorCorresponding Author
Gary TC Ko
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Gary TC Ko, MD, FRCPIFlat D, 4/F, Block BStaff QuarterPrince of Wales HospitalShatin, NTHong Kong.Tel: (852) 26323138;fax: (852) 26323108;e-mail: [email protected]Search for more papers by this authorGary WK Wong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorRisa Ozaki
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorWing-Yee So
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorPeter CY Tong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorJuliana CN Chan
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorAlice PS Kong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorKai-Chow Choi
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorCorresponding Author
Gary TC Ko
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Gary TC Ko, MD, FRCPIFlat D, 4/F, Block BStaff QuarterPrince of Wales HospitalShatin, NTHong Kong.Tel: (852) 26323138;fax: (852) 26323108;e-mail: [email protected]Search for more papers by this authorGary WK Wong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorRisa Ozaki
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorWing-Yee So
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorPeter CY Tong
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorJuliana CN Chan
a Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China; b Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong SAR, China; c Center for Epidemiology and Biostatistics, The Chinese University of Hong Kong, Hong Kong SAR, China; d Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong SAR, China; and e Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong SAR, China
Search for more papers by this authorAbstract
Background: Obesity is a growing global health problem. Obesity-associated inflammatory and metabolic consequences may vary in different ethnic populations, and data in Chinese adolescents are sparse. In this study, we analysed the clinical and biochemical factors associated with overweight and obesity in Chinese adolescents.
Methods: This is a cross-sectional cohort study with 2102 Chinese adolescents randomly selected from 14 secondary schools in Hong Kong. Clinical and biochemical parameters including inflammatory markers, among different groups stratified by degrees of obesity, were compared by multivariate logistic regression analysis.
Results: The median age was 16 yr (interquartile range: 14–17 yr) (45.6% boys and 54.4% girls). Among the boys, 16.5% were overweight and 6.8% were obese. The respective percentages in girls were 8.2 and 5.8%. Compared with the group with normal weight in both boys and girls, high systolic blood pressure (SBP), increased insulin resistance (by homoeostasis model assessment, HOMA-IR), elevated high-sensitivity C-reactive protein (hsCRP) level and low high-density lipoprotein cholesterol (HDL-C) level were independently associated with overweight/obesity. In boys, the respective odds ratio (95% CI) was 1.03 (1.01–1.05) for SBP, 21.0 (12.0–36.8) for HOMA-IR, 3.65 (2.10–6.35) for hsCRP and 0.24 (0.11–0.51) for HDL-C. In girls, the respective figures were 1.02 (1.00–1.04), 9.82 (5.65–17.1), 6.28 (3.12–12.6) and 0.18 (0.08–0.41). In girls, low-density lipoprotein cholesterol was also independently associated with overweight/obesity [1.56 (1.09–2.24)].
Conclusions: In Chinese adolescents, overweight/obesity is independently associated with SBP, insulin resistance, hsCRP and low HDL-C. Early intervention in overweight and obese adolescents may potentially retard the development of these cardiovascular risk factors.
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