ABO-incompatible kidney transplantation in children
Gunnar Tydén, MD, Department of Transplantation Surgery, Karolinska University Hospital, S-14186 Stockholm, SwedenTel.: +46 8 58580000Fax: +46 8 7743191E-mail: [email protected]
Abstract
Tydén G, Kumlien G, Berg UB. ABO-incompatible kidney transplantation in children. Pediatr Transplantation 2011: 15: 502–504. © 2011 John Wiley & Sons A/S.
Abstract: We designed a new protocol to enable safe ABO-incompatible kidney transplantation. The new protocol utilizes antigen-specific immunoadsorption rather than unspecific plasma exchange to remove existing anti A/B antibodies and rituximab rather than splenectomy to prevent rebound of antibodies. Sixty patients have so far been successfully transplanted with this protocol and 10 of those have been children. When compared with ABO-compatible transplantations, we could not find any differences in success rate, renal function, or adverse events.
