Volume 27, Issue 6 pp. 659-665
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Synthesis of α-thiophenylglycine peptides

Novel peptide substrates useful in the study of microbial peptide transport

WILLIAM D. KINGSBURY

Corresponding Author

WILLIAM D. KINGSBURY

Department of Medicinal Chemistry, Research and Development Division, Smith Kline and French Laboratories, Philadelphia, PA, USA

Department of Medicinal Chemistry Research and Development Division Smith Kline & French Laboratories 1500 Spring Garden Street Philadelphia, PA 19101 USASearch for more papers by this author
JEFFREY C. BOEHM

JEFFREY C. BOEHM

Department of Medicinal Chemistry, Research and Development Division, Smith Kline and French Laboratories, Philadelphia, PA, USA

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First published: June 1986
Citations: 13

Abstract

The synthesis of peptides useful for the investigation of microbial peptide transport is reported. These peptides, L-alanyl-L-2-thiophenylglycine (Ala-α-TPG), L-alanyl-L-2-thiophenylglycyl-L-alanine (Ala-α-TPG-Ala) and L-alanyl-L-alanyl-L-2-thiophenylglycine (Ala-Ala-α-TPG), contain a phenylthio group attached to the α carbon of glycine.

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