Volume 10, Issue 2 pp. 153-158
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STUDIES ON POLYPEPTIDES:

XXIV. Synthesis of the 5–17 and 1–17 Peptide Sequences of Rat Pancreatic Ribonuclease.*

Ingrid Voskuyl-Holtkamp

Corresponding Author

Ingrid Voskuyl-Holtkamp

Department of Organic Chemistry, Gorlaeus Laboratories of Leiden University, Leiden, The Netherlands

Dept. of Organic Chemistry Gorlaeus Laboratories Leiden University P.O. Box 75 Leiden The NetherlandsSearch for more papers by this author
Cecile Schattenkerk

Cecile Schattenkerk

Department of Organic Chemistry, Gorlaeus Laboratories of Leiden University, Leiden, The Netherlands

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First published: August 1977
Citations: 4

All amino acids, except glycine, were of the L-conifiguration. The following abbreviations are used: RNase S, the subtilisin modified bovine pancreatic ribonuclease; S-protein, the protein component obtained from RNase S; S-peptide, the polypeptide obtained from RNase S; RNase S‘, equimolar combination of S-peptide and S-protein; RNA, yeast ribonucleic acid. The abbreviations for the amino acids and protecting groups are those recommended by the IUPAC-IUB Commission on Biochemical Nomenclature, Biochemistry 11, (1972) 1726–1732.

Abstract

A description is given of the synthesis by fragment condensation of the peptides Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp and Gly-Glu-Ser-Arg-Glu-Ser-Ser-Ala-Asp-Lys-Phe-Lys-Arg-Gln-His-Met-Asp respectively corresponding to the 5–17 and 1–17 amino acid sequences of rat pancreatic ribonuclease.

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