Association of canine hypothyroidism with a common major histocompatibility complex DLA class II allele
Corresponding Author
L. J. Kennedy
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
*Dr Lorna J. Kennedy Centre for Integrated Genomic Medical Research Stopford Building Oxford Road Manchester M13 9PT UK Tel: 44 161 275 7316 Fax: 44 161 275 1617 e-mail: [email protected]Search for more papers by this authorS. Quarmby
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
Search for more papers by this authorG. M. Happ
Institute of Arctic Biology, University of Alaska, Fairbanks, AK, USA
Search for more papers by this authorA. Barnes
Faculty of Veterinary Sciences, University of Liverpool, Liverpool, UK
Search for more papers by this authorI. K. Ramsey
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
Search for more papers by this authorR. M. Dixon
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
Search for more papers by this authorN. S. Hillbertz
Swedish University of Agricultural Sciences, Uppsala, Sweden
Search for more papers by this authorW. E. R. Ollier
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
Search for more papers by this authorCorresponding Author
L. J. Kennedy
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
*Dr Lorna J. Kennedy Centre for Integrated Genomic Medical Research Stopford Building Oxford Road Manchester M13 9PT UK Tel: 44 161 275 7316 Fax: 44 161 275 1617 e-mail: [email protected]Search for more papers by this authorS. Quarmby
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
Search for more papers by this authorG. M. Happ
Institute of Arctic Biology, University of Alaska, Fairbanks, AK, USA
Search for more papers by this authorA. Barnes
Faculty of Veterinary Sciences, University of Liverpool, Liverpool, UK
Search for more papers by this authorI. K. Ramsey
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
Search for more papers by this authorR. M. Dixon
Faculty of Veterinary Medicine, University of Glasgow, Glasgow, UK
Search for more papers by this authorN. S. Hillbertz
Swedish University of Agricultural Sciences, Uppsala, Sweden
Search for more papers by this authorW. E. R. Ollier
Centre for Integrated Genomic Medical Research, University of Manchester, Manchester, UK
Search for more papers by this authorAbstract
Dogs exhibit a range of immune-mediated conditions including a lymphocytic thyroiditis which has many similarities to Hashimoto's thyroiditis in man. We have recently reported an association in Doberman Pinschers between canine hypothyroidism and a rare DLA class II haplotype that contains the DLA-DQA1*00101 allele. We now report a further series of 173 hypothyroid dogs in a range of breeds where a significant association with DLA-DQA1*00101 is shown.
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