A folate sensitive heritable fragile site at 19p13
Niels Tommerup
The John F. Kennedy Institute, Department of Medical Genetics, Glostrup
Search for more papers by this authorJohannes Nielsen
The Cytogenetic Laboratory, Århus Psychiatric Hospital, Denmark
Search for more papers by this authorMargareta Mikkelsen1
The John F. Kennedy Institute, Department of Medical Genetics, Glostrup
Search for more papers by this authorNiels Tommerup
The John F. Kennedy Institute, Department of Medical Genetics, Glostrup
Search for more papers by this authorJohannes Nielsen
The Cytogenetic Laboratory, Århus Psychiatric Hospital, Denmark
Search for more papers by this authorMargareta Mikkelsen1
The John F. Kennedy Institute, Department of Medical Genetics, Glostrup
Search for more papers by this authorAbstract
A fragile site at 19pl3 was found in the mother of a newborn girl with Downs syndrome. The fragile site was expressed in medium containing low folate and by addition of FdU, whereas high folate, thymidine and thymidine-analogues inhibited the expression. This fragile site may prove valuable for linkage studies on chromosome 19.
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