Relationship of serum cholesterol levels to atopy in the US population

M. B. Fessler

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

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R. Jaramillo,

R. Jaramillo

SRA International, Durham, NC, USA

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P. W. Crockett,

P. W. Crockett

SRA International, Durham, NC, USA

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D. C. Zeldin,

D. C. Zeldin

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

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M. B. Fessler,

M. B. Fessler

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

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R. Jaramillo,

R. Jaramillo

SRA International, Durham, NC, USA

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P. W. Crockett,

P. W. Crockett

SRA International, Durham, NC, USA

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D. C. Zeldin,

D. C. Zeldin

Laboratory of Respiratory Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC

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First published: 01 June 2010

https://doi.org/10.1111/j.1398-9995.2009.02287.x

Citations: 26

M. B. Fessler, MD
National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, PO Box 12233, Maildrop D2-01, Research Triangle Park, NC 27709, USA.
Tel.: +91 9 541 3701
Fax: +91 9 541 4133
E-mail: [email protected]

Edited by: Thomas Bieber and Hans-Uwe Simon

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Abstract

To cite this article: Fessler MB, Jaramillo R, Crockett PW, Zeldin DC. Relationship of serum cholesterol levels to atopy in the US population. Allergy 2010; 65: 859–864.

Background: Cholesterol promotes Th2 immunity and allergic inflammation in rodents; whether this occurs in humans is unclear. Reports of both direct and inverse associations between serum cholesterol and atopy in different populations suggest that race and/or other demographic variables may modify these relationships.

Aims of the study: To determine the relationships between levels of three serum cholesterol measures [total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), and non-HDL-C] and atopy in a sample representative of the US population.

Methods: Cross-sectional study of 6854 participants aged ≥6 years from the 2005–2006 National Health and Nutrition Examination Survey.

Results: In the overall population, adjusted odds ratios (AORs) per two-standard deviation increase in TC and non-HDL-C for biochemical atopy (defined as ≥1 allergen-specific IgE to 19 allergens) were 1.17 [95% confidence interval (CI), 1.00–1.38] and 1.19 (95% CI, 1.03–1.39), respectively. Interactions by race were noted for the two relationships (interaction P = 0.004 and P = 0.009, respectively) with non-Hispanic Whites (NHWs) having direct relationships [TC: AOR 1.27 (95% CI, 1.03–1.57); non-HDL-C: AOR 1.27 (95% CI, 1.03–1.56)] and non-Hispanic Blacks (NHBs) inverse relationships [TC: AOR 0.77 (95% CI, 0.62–0.95); non-HDL-C: AOR 0.86 (95% CI, 0.69–1.08)]. The adjusted HDL-C–atopy relationship was nonsignificant for NHWs and inverse for NHBs [AOR 0.77 (95% CI, 0.61–0.96)]. Relationships were independent of body mass index and serum C-reactive protein and unmodified by corticosteroid or statin usage. Results were similar using current hay fever/allergy as the atopy outcome.

Conclusions: There are marked inter-racial differences in the relationship between serum cholesterol and atopy in the US population.

Supporting Information

References

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Volume65, Issue7

July 2010

Pages 859-864

Relationship of serum cholesterol levels to atopy in the US population

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Relationship of serum cholesterol levels to atopy in the US population

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