Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma
Corresponding Author
L. Hasselmark
Dept. of Experimental Surgery, Thoracic Clinic, Stockholm, Sweden
Lena Hasselmark, Dept. of Experimental Surgery, Thoracic Clinic, Karolinska Hospital, S-104 01 Stockholm, SwedenSearch for more papers by this authorR. Malmgren
Dept. of Experimental Surgery, Thoracic Clinic, Stockholm, Sweden
Search for more papers by this authorG. Unge
Dept. of Thoracic Medicine, Karolinska Hospital, Stockholm, Sweden
Search for more papers by this authorO. Zetterström
Dept. of Thoracic Medicine, Karolinska Hospital, Stockholm, Sweden
Search for more papers by this authorCorresponding Author
L. Hasselmark
Dept. of Experimental Surgery, Thoracic Clinic, Stockholm, Sweden
Lena Hasselmark, Dept. of Experimental Surgery, Thoracic Clinic, Karolinska Hospital, S-104 01 Stockholm, SwedenSearch for more papers by this authorR. Malmgren
Dept. of Experimental Surgery, Thoracic Clinic, Stockholm, Sweden
Search for more papers by this authorG. Unge
Dept. of Thoracic Medicine, Karolinska Hospital, Stockholm, Sweden
Search for more papers by this authorO. Zetterström
Dept. of Thoracic Medicine, Karolinska Hospital, Stockholm, Sweden
Search for more papers by this authorAbstract
Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0±7.1 U/1011 platelets, which is significantly lower than that of 56.4±12 U/1011 platelets in the controls (P < 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.
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