Heparin-like anticoagulants in asthma
Corresponding Author
E. C. Lasser
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Elliott C. Lasser, M. D., Department of Radiology, M-032, University of California, San Diego, La Jolla, CA, 92093, U. S. A.Search for more papers by this authorR. A. Simon
Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California, U. S. A.
Search for more papers by this authorS. G. Lyon
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorA. E. Hamblin
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorR. Stein
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorCorresponding Author
E. C. Lasser
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Elliott C. Lasser, M. D., Department of Radiology, M-032, University of California, San Diego, La Jolla, CA, 92093, U. S. A.Search for more papers by this authorR. A. Simon
Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, California, U. S. A.
Search for more papers by this authorS. G. Lyon
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorA. E. Hamblin
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorR. Stein
Department of Radiology, University of California, San Diego, School of Medicine, La Jolla, California, and the
Search for more papers by this authorAbstract
In a previous study, and in the present study, we have found that the baseline plasma samples of patients with asthma contain average levels of an endogenous heparin-like material (EHM) that is significantly higher than that noted in non-allergic, non-asthmatic controls. This material appears to have properties of both heparin and heparan sulfate. Three out of six patients responding to inhalational antigen challenge displayed an acute increment in EHM concentration that coincided with a fall in FEV1 values. The relation of EHM concentration to provoked asthma, or to asthma in general, remains to be determined.
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