A Dysbalanced Immune System in Cryptogenic Lennox-Gastaut Syndrome
Corresponding Author
B. G. M. VAN ENGELEN
Institute of Neurology, Amsterdam, The Netherlands
Baziel G. M. van Engelen, MD, Department of Neurology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The NetherlandsSearch for more papers by this authorC. M. R. WEEMAES
Department of Paediatrics, Amsterdam, The Netherlands
Search for more papers by this authorW. O. RENIER
Institute of Neurology, Amsterdam, The Netherlands
Search for more papers by this authorJ. A. J. M. BAKKEREN
Department of Paediatrics, Amsterdam, The Netherlands
Search for more papers by this authorG. F. BORM
Department of Medical Statistics, University Hospital, Nijmegen, Amsterdam, The Netherlands
Search for more papers by this authorP. F. W. STRENGERS
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
Search for more papers by this authorCorresponding Author
B. G. M. VAN ENGELEN
Institute of Neurology, Amsterdam, The Netherlands
Baziel G. M. van Engelen, MD, Department of Neurology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB Nijmegen, The NetherlandsSearch for more papers by this authorC. M. R. WEEMAES
Department of Paediatrics, Amsterdam, The Netherlands
Search for more papers by this authorW. O. RENIER
Institute of Neurology, Amsterdam, The Netherlands
Search for more papers by this authorJ. A. J. M. BAKKEREN
Department of Paediatrics, Amsterdam, The Netherlands
Search for more papers by this authorG. F. BORM
Department of Medical Statistics, University Hospital, Nijmegen, Amsterdam, The Netherlands
Search for more papers by this authorP. F. W. STRENGERS
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam, The Netherlands
Search for more papers by this authorAbstract
In children with cryptogenic Lennox-Gastaut syndrome we found a functionally impaired humoral immune response to a primary antigen (haemocyanin), despite signs of a triggered immune system consisting of elevated IgG concentrations. This combination of immunological findings, considered to be the expression of a dysbalanced-triggered as well as functionally impaired-immune system, has also been described in an auto-immune disease like systemic lupus erythaematodes in humans, and in genetically epilepsy-prone rats. The interactions between the immune system and the nervous system in Lennox-Gastaut syndrome will be discussed.
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